Reintroduction of foot-and-mouth disease in Argentina:: characterisation of the isolates and development of tools for the control and eradication of the disease
Reintroduction of foot-and-mouth disease in Argentina:: characterisation of the isolates and development of tools for the control and eradication of the disease
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DOI：
10.1016/j.vaccine.2004.06.040
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发表时间：
2004-10-22
期刊：
影响因子：
5.5
通讯作者：
Palma, EL
中科院分区：
文献类型：
--
作者：
Mattion, N;König, G;Palma, EL
本文描述了阿根廷2000-2002年口蹄疫流行期间分离的口蹄疫病毒（FMDV）毒株的抗原和分子特征，以及实施的疾病控制策略。涉及两种不同的FMDV血清型，O型和A型。在研究的各种田间分离株中，鉴定出两种不同的O 1谱系（菌株Corrientes/00和米西奥内斯/00）和两种血清型A谱系（A/Argentina/00和A/Argentina/01原型）。这些菌株的基因组序列与以前的区域，分离物和疫苗株的序列进行了比较。O 1株与区域株相关，而A型株与区域株关系较远。更新紧急情况下使用的疫苗的抗原成分是一个关键问题。因为在实施疫苗接种计划后不久，疫情就停止了。在采取严格的控制措施和使用含有O 1/Campos株的疫苗后，O 1株很快从田间消失。然而，在A血清型菌株的情况下，情况不同，因为使用含有菌株A24/Cruzeiro的疫苗仅在重新接种后才产生可接受的保护水平。因此，将新的田间菌株A/Argentina/00和A/Argentina/01纳入疫苗中，从而有效控制了该疾病。病毒的传播大大减少了，这表现在爆发的数量和具有抗非结构蛋白抗体的动物数量显著减少。随后在牛群中检测到令人满意的保护性抗体水平（高于75%的保护）。2002年1月以后没有爆发疫情，表明疫情得到控制。(C)2004爱思唯尔有限公司保留所有权利。
This paper describes the antigenic and molecular characterisation of foot-and-mouth disease virus (FMDV) strains isolated during the 2000-2002 epidemic in Argentina, and the strategy implemented for disease control. Two different FMDV serotypes, O and A, were involved. Of the various field isolates studied, two distinct O1 lineages (strains Corrientes/00 and Misiones/00) and two serotype A lineages (A/Argentina/00 and A/Argentina/01 prototypes) were identified. The genome sequences of these strains were compared with sequences of previous regiona, isolates and sequences of vaccine strains. O1 strains were found to be related to regional strains while serotype A strains were found to be more distanced from them. The updating of the antigenic composition of the vaccines used in the emergency was a key issue. since the outbreaks stopped shortly after the implementation of the vaccination programs. The O1 strains quickly disappeared from the field following strict control measures and the use of vaccines containing O1/Campos strain. However, in the case of the A serotype strains, the situation was different, since the use of a vaccine containing strain A24/Cruzeiro yielded acceptable levels of protection only after re-vaccination. Therefore, the new field strains A/Argentina/00 and A/Argentina/01 were incorporated into the vaccine, leading to an effective control of the disease. Viral circulation greatly diminished, as indicated by the significant reduction in the number of outbreaks and in the number of animals with antibodies against non-structural proteins. Satisfactory levels of protective antibodies were subsequently detected in the cattle population (above 75% protection). The absence of outbreaks after January 2002 indicated that the epidemic was controlled. (C) 2004 Elsevier Ltd. All rights reserved.