Screening for lung cancer using low dose CT scanning
Screening for lung cancer using low dose CT scanning
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DOI：
10.1136/thx.2003.008821
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发表时间：
2004-03-01
期刊：
影响因子：
10
通讯作者：
Costello, RW
中科院分区：
文献类型：
--
作者：
MacRedmond, R;Logan, PM;Costello, RW
背景：肺癌是爱尔兰最常见的癌症相关死亡原因。大多数肺癌在确诊时是不能手术的，因此总的5年生存率不到10%。前瞻肺癌检测研究的目的是评估低剂量胸部CT扫描能否在城市高危人群中发现早期无症状肺癌。方法：449名受试者年龄中值55岁(50-74岁)，中位年龄55岁(50-74岁)，中位吸烟年限45年(10-160年)，无癌症病史，医学上适合接受胸部手术。在知情同意后，对所有受试者进行LDCCT。直径大于或等于10 mm的非钙化结节(NCNs)接受活检。建议对NCN进行间隔6、12和24个月的LDCCT随访，排除增长
Background: Lung cancer is the most common cause of cancer related death in Ireland. The majority of lung cancers are inoperable at the time of diagnosis and consequently the overall 5 year survival is less than 10%. The objective of the ProActive Lung Cancer Detection (PALCAD) study was to evaluate whether low dose chest computed tomographic scanning (LDCCT) can detect early stage asymptomatic lung cancer in a high risk urban population.Methods: Four hundred and forty nine subjects of median age 55 years (range 50-74) with a median pack year smoking history of 45 years (range 10-160), with no previous cancer history and medically fit to undergo thoracic surgery were recruited. After informed consent, LDCCT was performed on all subjects. Non-calcified nodules (NCNs) of greater than or equal to10 mm in diameter were referred for biopsy. Follow up with interval LDCCT at 6, 12 and 24 months to exclude growth was recommended for NCNs