Serum IL-1beta, IL-6, IL-8, and TNF-alpha levels in early diagnosis and management of neonatal sepsis.
Serum IL-1beta, IL-6, IL-8, and TNF-alpha levels in early diagnosis and management of neonatal sepsis.
复制标题
在新生儿败血症的早期诊断和管理中，血清IL-1Beta，IL-6，IL-8和TNF-Alpha水平。
DOI：
10.1155/2007/31397
复制
发表时间：
2007
影响因子：
4.6
通讯作者：
Yilmaz, Erdal
中科院分区：
文献类型：
--
作者：
Kurt, A Nese Citak;Aygun, A Denizmen;Godekmerdan, Ahmet;Kurt, Abdullah;Dogan, Yasar;Yilmaz, Erdal
瞄准。检测新生儿败血症发病时及治疗后血清IL-1、IL-6、IL-8、肿瘤坏死因子-α水平，探讨其对新生儿败血症的随访意义。方法：研究方法。这项前瞻性研究是对因新生儿败血症住院的新生儿进行的，这些新生儿被分类为培养证实的败血症()、培养阴性的败血症()和健康新生儿()。结果。在诊断时，培养证实的脓毒症患者的血清IL-1、IL-6、IL-8和肿瘤坏死因子水平显著高于对照组()。在诊断时，培养阳性和阴性脓毒症患者的IL-1、IL-6、IL-8和TNF-α水平显著高于抗生素治疗后第7天的水平。结论。血清IL-1、IL-6、IL-8和TNF-α是炎症介质，可用于新生儿败血症的诊断和疗效评估。
Aim. To determine serum IL-1, IL-6, IL-8, and TNF- levels in neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow up. Methods. This prospective study was performed on newborns who were hospitalized for neonatal sepsis and who were classified as culture-proven sepsis (), as culture-negative sepsis (), and as healthy newborns (). Results. At the time of diagnosis, serum IL-1, IL-6, IL-8, and TNF- levels of culture-proven sepsis were significantly higher than those of the control groups (). At the time of diagnosis, IL-1, IL-6, IL-8, and TNF- levels of culture-proven sepsis and culture-negative sepsis were significantly higher than levels at the seventh day after antibiotic treatment. Conclusion. Serum IL-1, IL-6, IL-8, and TNF- are mediators of inflammation and can be used at the diagnosis and at the evaluation of the therapeutic efficiency in neonatal sepsis.