Questioning the depolarizing effects of GABA during early brain development
Questioning the depolarizing effects of GABA during early brain development
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DOI：
10.1152/jn.00293.2011
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发表时间：
2011-09-01
影响因子：
2.5
通讯作者：
Khakhalin, Arseny S.
中科院分区：
文献类型：
--
作者：
Khakhalin, Arseny S.
哈哈林AS质疑GABA在早期大脑发育中的去极化作用。J Neurophysiol 106：1065-1067，2011.首次发表于2011年5月18日; doi：10.1152/jn.00293.2011.-在大脑发育的早期，γ-氨基丁酸（GABA）是成年大脑中主要的抑制性神经递质，被认为是兴奋性神经递质的重要来源。然而，这一观点最近受到一系列研究的挑战，这些研究声称GABA的兴奋作用是由于非生理性的体外实验条件。在这篇文章中，我们的目的是总结支持和挑战传统观点的结果，并指出两种立场的一些优点和缺点。
Khakhalin AS. Questioning the depolarizing effects of GABA during early brain development. J Neurophysiol 106: 1065-1067, 2011. First published May 18, 2011; doi:10.1152/jn.00293.2011.-During early brain development, gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the adult brain, has been thought to be an important source of excitatory neurotransmission. This view, however, was recently challenged by a series of studies that claim that the excitatory effect of GABA is due to non-physiological in vitro experimental conditions. In this article, we aim to summarize results that support and challenge the traditional point of view, and indicate some strong and weak points of both positions.