Total respiratory resistance and reactance as a measurement of response to bronchial challenge with histamine.
Total respiratory resistance and reactance as a measurement of response to bronchial challenge with histamine.
复制标题
总呼吸阻力和电抗作为对组胺支气管激发反应的测量。
DOI：
--
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
M. Demedts
中科院分区：
文献类型：
--
作者：
J. Noord;J. Clement;K. V. D. Woestijne;M. Demedts
将强迫振荡技术检测组胺支气管激发试验的气道反应的潜力与FEV1和体积描记SGaw进行了比较。在53例有阵发性喘息史和基础气道阻力正常的受试者中，我们通过连续加倍组胺浓度进行支气管激发，直到FEV1下降15%或以上或组胺浓度达到16 mg/ml。对于基线值，FEV1的平均受试者内变异系数为2.8%，SGaw的受试者内变异系数为7.4%，6赫兹振荡呼吸电导的受试者内变异系数为8.7%(1/RRS6)，平均振荡呼吸电导的受试者内变异系数为7.7%(2-26赫兹之间)(1/RRS)。后一系数允许计算以下阈值：PD15FEV1、PD40SGaw、PD47 1/RRS 6和PD42 1/RRS。偶然超过这些水平的可能性几乎为零。组胺刺激引起6 HzRRS(Rrs6)、RRS和呼吸电抗(XRS)的平均水平、RRS和XRS的斜率随频率的变化以及RRS-频率曲线的平均曲率发生显著变化。对激发前和激发后的差值进行的多因素分析表明，对检测组胺效应最敏感的参数依次为：Sgaw、1/Rs6、1/RRS、FEV1、FVC和1/VTG的相对变化，其次是XRS的绝对变化和RRS-频率关系的平均斜率。
The potential of the forced oscillation technique to detect the airway response on histamine bronchial challenge tests was compared with that of FEV1 and plethysmographic SGaw. In 53 subjects with a history of episodic wheezing and a normal baseline airway resistance, we carried out bronchial challenges with successively doubling concentrations of histamine until FEV1 had dropped by 15% or more or a concentration of 16 mg/ml histamine was reached. For the baseline values, a mean within-subject coefficient of variation was found of 2.8% for FEV1, 7.4% for SGaw, 8.7% for the oscillatory respiratory conductance at 6 Hz (1/Rrs6), and 7.7% for the mean oscillatory respiratory conductance (between 2 and 26 Hz) (1/Rrs). The latter coefficients allow the calculation of the following threshold values: PD15FEV1, PD40SGaw, PD47 1/Rrs6, and PD42 1/Rrs. The probability of exceeding these levels by chance is virtually zero. Histamine challenge caused significant absolute changes in Rrs at 6 Hz (Rrs6), in mean level of Rrs and of respiratory reactance (Xrs), in slope of Rrs and Xrs versus frequency, and in mean curvature of Rrs-frequency curve. A multivariate analysis of the differences between prechallenge and postchallenge values showed that the parameters with the best sensitivity to detect the effect of histamine were, in decreasing order: the relative change of SGaw, of 1/Rrs6, of 1/Rrs, of FEV1, of FVC, and of 1/Vtg, followed by the absolute change of Xrs and of the average slope of the Rrs-frequency relationship.(ABSTRACT TRUNCATED AT 250 WORDS)