Impact of alcohol use on EEG dynamics of response inhibition: a cotwin control analysis
Impact of alcohol use on EEG dynamics of response inhibition: a cotwin control analysis
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DOI：
10.1111/adb.12481
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发表时间：
2018-01-01
影响因子：
3.4
通讯作者：
Iacono, William G.
中科院分区：
文献类型：
--
作者：
Harper, Jeremy;Malone, Stephen M.;Iacono, William G.
研究表明，酒精滥用与行为去抑制有关，但控制这种关系的神经生理机制在很大程度上仍然未知。最近的研究表明，成功的抑制和认知控制涉及电生理θ-波段动力学，包括内侧额叶皮层（MFC）的功率增强和MFC和背侧前额叶皮层（dPFC）区域之间的功能连接，这可能会被酒精滥用破坏。此外，研究表明，与男性相比，女性经历饮酒的负面身体和神经认知相关性的风险更高。本研究测试的假设，酒精滥用有一个有害的影响θ-波段反应抑制脑电动力学的样本中的300个24岁的同性双胞胎。一个cotwin控制（CTC）的设计被用来解开发病前的风险，酒精使用的因果关系的影响，酒精暴露。在反应抑制期间，饮酒与θ波段MFC功率和MFC-dPFC连接呈负相关，这种影响在女性中更强。CTC分析表明，对于女性，nogo相关的θ波段MFC功率和MFC-dPFC连接性降低与酒精暴露的潜在有害因果效应一致。这些研究结果表明，减少θ-波段MFC功率和MFC-dPFC连接可能是神经生理机制的基础酒精相关的去抑制。虽然是初步的，这些结果表明，在成年初期的酒精使用的规范水平有潜在的性别特异性的因果关系的反应抑制脑电图动力学的影响，因此有潜在的重大公共卫生影响。
Research indicates that alcohol misuse is associated with behavioral disinhibition, but the neurophysiological mechanisms governing this relationship remain largely unknown. Recent work suggests that successful inhibition and cognitive control involve electrophysiological theta-band dynamics, including medial frontal cortex (MFC) power enhancement and functional connectivity between the MFC and dorsal prefrontal cortex (dPFC) regions, which may be disrupted by alcohol misuse. In addition, research suggests that, compared to men, women are at heightened risk of experiencing the negative physical and neurocognitive correlates of drinking. The present study tested the hypothesis that alcohol misuse has a deleterious effect on theta-band response inhibition EEG dynamics in a sample of 300 24-year-old same-sex twins. A cotwin control (CTC) design was used to disentangle premorbid risk for alcohol use from the causal effects of alcohol exposure. Drinking was negatively associated with theta-band MFC power and MFC-dPFC connectivity during response inhibition, and this effect was stronger among women. The CTC analysis suggested that, for women, reduced nogo-related theta-band MFC power and MFC-dPFC connectivity were both consistent with the potential deleterious causal effects of alcohol exposure. These findings suggest that diminished theta-band MFC power and MFC-dPFC connectivity may be neurophysiological mechanisms underlying alcoholrelated disinhibition. Although preliminary, these results suggest that normative levels of alcohol use during emerging adulthood have potential sex-specific causal effects on response inhibition EEG dynamics, and thus have potentially significant public health implications.