A convergent stereoselective synthesis of quinolizidines and indolizidines: chemoselective coupling of 2-hydroxymethyl-substituted allylic silanes with imines.
A convergent stereoselective synthesis of quinolizidines and indolizidines: chemoselective coupling of 2-hydroxymethyl-substituted allylic silanes with imines.
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喹啉西啶和吲哚西啶的聚合立体选择性合成：2-羟甲基取代的烯丙基硅烷与亚胺的化学选择性偶联。
DOI：
10.1021/ja908504z
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发表时间：
2009
影响因子：
15
通讯作者：
Micalizio,GlennC
中科院分区：
文献类型：
--
作者：
Yang,Dexi;Micalizio,GlennC
描述了通过2-羟甲基取代烯丙基硅烷和亚胺之间的化学选择性烯丙基转移聚合合成立体吲哚吡啶和喹啉吡啶。总的来说，包含三个立体中心和多达四个融合环的高取代杂环可以从相对简单的偶联伙伴两步获得。
A convergent synthesis of stereodefined indolizidines and quinolizidines through chemoselective allyl transfer between 2-hydroxymethyl-substituted allylic silanes and imines is described. Overall, highly substituted heterocycles that contain three stereogenic centers and up to four fused rings can be accessed in two steps from relatively simple coupling partners.