Molecular evolution of the human immunodeficiency and related viruses.
Molecular evolution of the human immunodeficiency and related viruses.
复制标题
DOI：
10.1093/oxfordjournals.molbev.a040495
复制
发表时间：
1988-05
影响因子：
10.7
通讯作者：
S. Yokoyama;L. Chung;T. Gojobori
中科院分区：
文献类型：
--
作者：
S. Yokoyama;L. Chung;T. Gojobori
通过比较编码逆转录酶和核酸内切酶/整合酶的pol基因两个区域的核苷酸序列，构建了不同人类免疫缺陷病毒1型（HIV 1）和2型（HIV 2）、慢病毒和肿瘤病毒的系统发育树。分析表明：（1）不同的HIV 1毒株形成一个簇，它们的共同祖先与HIV 2的祖先分离;（2）HIV 1和HIV 2毒株的共同祖先与慢病毒的共同祖先分离;（3）慢病毒组的共同祖先与肿瘤病毒的共同祖先分离早于此。HIV 1和HIV 2毒株之间的分歧似乎发生在200多年前，这意味着艾滋病已经存在了很长一段时间，但没有被发现。此外，非同义的变化在时间上是一致的，而同义的变化在不同的谱系中变化更大。
A phylogenetic tree for different human immunodeficiency viruses type 1 (HIV1) and type 2 (HIV2), lentiviruses, and oncoviruses has been constructed by comparing the nucleotide sequences of the two regions of their pol genes that encode the reverse transcriptase and endonuclease/integrase. The analysis indicates that (1) different HIV1 strains form one cluster and their common ancestor diverged from the ancestor of HIV2, (2) the common ancestor of the HIV1 and HIV2 strains diverged from that of the lentivirus, and (3) the common ancestor of the lentivirus group and that of the oncoviruses diverged earlier than that. Divergence between the HIV1 and HIV2 strains seems to have occurred greater than 200 years ago, implying that AIDS has existed for a long time but went undetected. Furthermore, nonsynonymous changes are occurring uniformly through time, whereas synonymous changes are more variable among different lineages.