Deficiency in androgens and upregulation of insulin-like growth factor-1 are involved in high bone turnover in men receiving androgen deprivation therapy for prostate cancer
Deficiency in androgens and upregulation of insulin-like growth factor-1 are involved in high bone turnover in men receiving androgen deprivation therapy for prostate cancer
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DOI：
10.1016/j.ghir.2012.04.003
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发表时间：
2012-06-01
影响因子：
1.4
通讯作者：
Takahashi, Kota
中科院分区：
文献类型：
--
作者：
Ishizaki, Fumio;Hara, Noboru;Takahashi, Kota
目的：本研究旨在阐明雄激素剥夺治疗（ADT）期间高骨转换的机制，即睾酮、肾上腺雄激素和胰岛素样生长因子-1（IGF-I）的成骨内分泌活性，并确定ADT期间反映骨矿物质密度（BMD）的标志物。设计：对70例局限性前列腺癌患者进行ADT治疗前、后6个月的骨密度、血、尿标本检测。ADT治疗前，血清游离睾酮、硫酸脱氢表雄酮（DHEA-S）、雄烯二酮和IGF-I水平与BMD相关（分别为rs = 0.344，p = 0.004; rs = 0.264，p = 0.027; rs = 0.329，p = 0.005; rs = 0.300，p = 0.012）。血清IGF-I水平与治疗前BMD独立相关（多变量p = 0.001）。ADT后这些关系消失（p分别为0.519、0.316、0.116和0.597）。ADT后，血清游离睾酮水平降低（7.9 - 0.2 pg/mL），DHEA-S和雄烯二酮也降低（分别为3.6 - 2.3 μ mol/L和5.6 - 2.9 nmol/L）（p
Objective: This study was performed to elucidate the mechanism of high bone turnover during androgen deprivation therapy (ADT) in terms of osteogenic endocrine activity by testosterone, adrenal androgens, and insulin-like growth factor-1 (IGF-I), and to identify markers reflecting the bone mineral density (BMD) during ADT.Design: BMD and samples of blood and urine were studied before and after 6 months of ADT in 70 patients with localized prostate cancer.Results: Before ADT, serum free-testosterone, dehydroepiandrosterone sulfate (DHEA-S), androstenedione, and IGF-I levels were correlated with BMD (rs = 0.344, p = 0.004; rs = 0.264, p = 0.027; rs = 0.329, p = 0.005; rs = 0.300, p = 0.012, respectively). The serum IGF-I level was independently correlated with the pretreatment BMD (Multivariate p = 0.001). These relationships disappeared after ADT (p = 0.519, 0.316, 0.116, and 0.597, respectively). After ADT, serum levels of free-testosterone decreased (7.9 to 0.2 pg/mL), and DHEA-S and androstenedione were also reduced (3.6 to 2.3 mu mol/L and 5.6 to 2.9 nmol/L, respectively) (p