Odor-concentration coding in the guinea-pig piriform cortex
Odor-concentration coding in the guinea-pig piriform cortex
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DOI：
10.1016/j.neuroscience.2004.09.059
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发表时间：
2005-01-01
期刊：
影响因子：
3.3
通讯作者：
Onoda, N
中科院分区：
文献类型：
--
作者：
Sugai, T;Miyazawa, T;Onoda, N
通过光学成像的内在信号，我们证明了一个可能的代码气味浓度在前梨状皮质的豚鼠。气味诱导的皮层激活，主要起源于第二层，出现在一个狭窄的带鼻沟下的外侧嗅道，对应于前梨状皮质的背侧部分。较低的浓度激活的乐队的喙部区域，而较高的产生尾部扩散激活，并在该网站的神经激活达到最大程度取决于气味浓度。不同的气味与低浓度产生不同的，但有点重叠的模式，在喙区的乐队，有限程度的皮质活动可能是一个焦点域的每种气味。然而，很难判断气味特异性区域是否出现在前梨状皮质中，因为强刺激诱导了大量重叠的模式。此外，激活的总面积与浓度的0.5-0.9次方成比例增加。重要的是，这些成像结果证实了单位记录，这表明在皮层神经元之间的气味敏感性的喙尾梯度。我们的研究结果表明，前梨状皮质的背侧部分可能与气味浓度。因此，除了招募更多的嗅觉感觉细胞和肾小球在响应更强的刺激，在轴突的突起从二尖瓣/簇状细胞和/或在协会纤维的喙尾梯度可能发挥重要作用，在前梨状皮质的气味浓度编码。(C)2005年IBRO。由爱思唯尔有限公司出版。保留所有权利。
By optical imaging of intrinsic signals, we demonstrated a possible code for odor concentration in the anterior piriform cortex of the guinea-pig. Odor-induced cortical activation, which primarily originated in layer II, appeared in a narrow band beneath the rhinal sulcus over the lateral olfactory tract, corresponding to the dorsal part of the anterior piriform cortex. Lower concentrations activated the rostral region of the band, whereas higher ones generated caudally spreading activation, and the site at which neural activation reached its maximum extent depended upon odor concentration. Different odors with low concentrations generated distinct but somewhat overlapping patterns in the rostral region of the band; the limited extent of cortical activity may be one focal domain for each odor. It was hard to judge, however, that odor-specific domains appeared in the anterior piriform cortex, because the strong stimuli induced largely overlapping patterns. Furthermore, the total area activated increased in proportion to concentrations raised to a power of 0.5-0.9. Importantly, these imaging results were confirmed with unit recordings which indicated a rostro-caudal gradient in odor-sensitivity among cortical neurons. Our results suggest that the dorsal part of the anterior piriform cortex may be associated with odor concentration. Therefore, in addition to recruitment of more olfactory sensory cells and glomeruli in response to stronger stimuli, a rostro-caudal gradient in axonal projections from mitral/tufted cells and/or in association fibers may play an important role in odor-concentration coding in the anterior piriform cortex. (C) 2005 IBRO. Published by Elsevier Ltd. All rights reserved.