Dydrogesterone in threatened abortion: Pregnancy outcome
Dydrogesterone in threatened abortion: Pregnancy outcome
复制标题
DOI：
10.1016/j.jsbmb.2005.08.013
复制
发表时间：
2005-12-01
影响因子：
4.1
通讯作者：
Jamil, MA
中科院分区：
文献类型：
--
作者：
Omar, MH;Mashita, MK;Jamil, MA
目的：探讨妊娠早期先兆流产患者应用强孕酮治疗是否能改善妊娠结局。设计：前瞻性开放研究。研究对象：在13周前到妇产科门诊就诊的孕妇中，有阴道出血的孕妇进入本研究。有反复流产史的女性被排除在外。方法：符合条件的受试者被随机分为两组，一组接受达卓酮40 mg，然后每日两次10 mg，连续一周；另一组接受保守治疗。结果：共招募了105名女性。在治疗前状态方面，两组之间没有统计学上的显著差异。服用达卓酮的妇女继续妊娠成功率(95.9%)显著高于接受保守治疗的妇女(86.3%)(p=0.037)。用药与不用药成功率的优势比为3.773(95%可信区间：1.009~14.108)。结论：在无反复流产史的妇女中，黄体支持加用强孕酮可降低早孕先兆流产的妊娠失败率。(C)2005爱思唯尔有限公司。保留所有权利。
Objective: To determine whether therapy with dydrogesterone in threatened abortion during the first trimester of pregnancy will improve pregnancy outcome.Design: Prospective open study.Subjects: Pregnant women presenting to the obstetric and gynaecology clinic admitting center with vaginal bleeding before 13 weeks gestation were evaluated for entry into the study. Women were excluded if they had a history of recurrent miscarriage.Method: Eligible subjects were randomized to receive either dydrogesterone 40 mg stat dose followed by 10 mg twice a day for one week or conservative therapy.Results: One hundred and 54 women were recruited. There was no statistically significant differences between the two groups with regard to pre-treatment status. The continuing pregnancy success rate was significantly (p=0.037) higher in women treated with dydrogesterone (95.9%) compared with women who received conservative treatment (86.3%). The odds ratio of the success rate between dydrogesterone treatment and non-treatment was 3.773 (95% confidence interval: 1.009-14.108).Conclusion: Corpus luteal support with dydrogesterone has been shown to reduce the incidence of pregnancy loss in threatened abortion during the first trimester in women without a history of recurrent abortion. (c) 2005 Elsevier Ltd. All rights reserved.