Response of heterogeneous ribonuclear proteins (hnRNP) to ionising radiation and their involvement in DNA damage repair.
Response of heterogeneous ribonuclear proteins (hnRNP) to ionising radiation and their involvement in DNA damage repair.
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DOI：
10.1080/09553000903009548
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发表时间：
2009-08
影响因子：
2.6
通讯作者：
Woloschak GE
中科院分区：
文献类型：
--
作者：
Haley B;Paunesku T;Protić M;Woloschak GE
目的：探讨核内不均一核糖核蛋白（hnRNP）与DNA损伤修复的关系，特别是电离辐射（IR）对DNA损伤修复的影响。对文献中与hnRNP、IR和DNA修复主题相关的论文进行了检查。HnRNP A18、B1、C1/C2和K分别与DNA损伤反应（DDR）途径中的重要蛋白相互作用，结合DNA依赖性蛋白激酶（DNA-PK）、Ku抗原（Ku）和肿瘤抑制蛋白53（p53）。值得注意的是，hnRNP A18、B1、K、P2和L表达的不规则性与癌症和放射敏感性有关。16种不同的hnRNP蛋白在IR后表现出mRNA转录或蛋白质量的变化。hnRNP对IR的各种蛋白质修饰也被注意到：hnRNP A18，C1/C2和K被磷酸化; hnRNP C1/C2是凋亡蛋白酶的靶点; hnRNP K的降解受鼠双微泛素连接酶（MDM 2）控制。有证据表明，hnRNP A1、A18、A2/B1、C1/C2、K和P2通过促进IR后的同源重组（HR）或非同源末端再连接（NHEJ）修复途径在调节双链断裂（DSB）修复途径中起作用。HnRNP蛋白在暴露于IR后协调修复途径中起关键作用，通过蛋白质-蛋白质相互作用和关键修复和应激反应mRNA的转录调控。特别是，几种hnRNP蛋白在协调HR或NHEJ的选择以修复由IR引起的DSB中至关重要。
To determine the relationship between heterogeneous nuclear ribonucleoproteins (hnRNP) and DNA repair, particularly in response to ionizing radiation (IR). The literature was examined for papers related to the topics of hnRNP, IR and DNA repair. HnRNP orchestrate the processing of mRNA to which they are bound in response to IR. HnRNP A18, B1, C1/C2 and K interact with important proteins from DNA Damage Response (DDR) pathways, binding DNA-dependent protein kinase (DNA-PK), the Ku antigen (Ku) and tumor suppressor protein 53 (p53) respectively. Notably, irregularities in the expression of hnRNP A18, B1, K, P2 and L have been linked to cancer and radiosensitivity. Sixteen different hnRNP proteins have been reported to show either mRNA transcript or protein quantity changes following IR. Various protein modifications of hnRNP in response to IR have also been noted: hnRNP A18, C1/C2 and K are phosphorylated; hnRNP C1/C2 is a target of apoptotic proteases; and hnRNP K degradation is controled by murine double minute ubiquitin ligase (MDM2). Evidence points to a role for hnRNP A1, A18, A2/B1, C1/C2, K and P2 in regulating double-stranded break (DSB) repair pathways by promoting either homologous recombination (HR) or non-homologous end rejoining (NHEJ) repair pathways following IR. HnRNP proteins play a pivotal role in coordinating repair pathways following exposure to IR, through protein-protein interactions and transcript regulation of key repair and stress response mRNA. In particular, several hnRNP proteins are critical in coordinating the choice of HR or NHEJ to repair DSB caused by IR.
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影响因子：
56.9
作者：
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通讯作者：
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