The effectiveness of intracytoplasmic sperm injection combined with piezoelectric stimulation in infertile couples with total fertilization failure
The effectiveness of intracytoplasmic sperm injection combined with piezoelectric stimulation in infertile couples with total fertilization failure
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DOI：
10.1016/j.fertnstert.2009.03.107
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发表时间：
2010-08-01
影响因子：
6.7
通讯作者：
Sonmezer, Murat
中科院分区：
文献类型：
--
作者：
Baltaci, Volkan;Ayvaz, Oezge Uener;Sonmezer, Murat
目的：评估卵胞浆内单精子注射（ICSI）结合压电刺激治疗有完全受精失败（TFF）史的不孕夫妇的有效性。设计：前瞻性对照试验。设置：临床IVF实验室。患者：71对夫妇接受ICSI对兄弟姐妹卵母细胞至少有一个以前的ICSI尝试与TFF干预：ICSI或ICSI与压电激活主要结果测量：受精率结果：患者被分配到两组：组I包括21例患者只有一个以前的TFF和组II包括50例患者有一个以上的以前的TFF。总的来说，在78个卵母细胞检索中共检索到823个中期II（MII）卵母细胞。在I组中，对123/211（58.2%）的MII卵母细胞（IA组）应用结合压电刺激的ICSI，而对88/211（41.8%）的MII卵母细胞（IB组）应用标准ICSI程序。受精率IA组为62%，IB组为12%。在第二组中，压电激活施加在所有612 MII卵母细胞，其中296（48.3%）受精。植入率和妊娠/胚胎移植率分别为30.6%和44.1%.Conclusions（s）：压电激活似乎可以改善有TFF病史患者的IVF结局。（Fertil Steril（R）2010; 94：900-4. (c)美国生殖医学会（American Society for Reproductive Medicine）
Objective: To assess the effectiveness of intracytoplasmic sperm injection (ICSI) combined with piezoelectric stimulation in infertile couples with a history of total fertilization failure (TFF).Design: Prospective controlled trial.Setting: Clinical IVF laboratory. Patient(s): Seventy-one couples undergoing ICSI on sibling oocytes having at least one previous ICSI attempt with TFF.Intervention(s): ICSI or ICSI with piezoelectric activation.Main Outcome Measure(s): Fertilization rate.Result(s): The patients were allocated to two groups: group I included 21 patients with only one previous TFF and group II included 50 patients with more than one previous TFF. Collectively, a total of 823 metaphase II (MII) oocytes were retrieved in 78 oocyte retrievals. In Group I, combined ICSI with piezoelectric stimulation was applied to 123/211 (58.2%) of MII oocytes (group IA), whereas standard ICSI procedure was applied to 88/211 (41.8%) of MII oocytes (group IB). The fertilization rate was 62% and 12% in group IA and group IB respectively. In group II, piezoelectric activation was applied in all 612 MII oocytes, of which 296 (48.3%) were fertilized. The rates for implantation and pregnancy/embryo transfer were obtained as 30.6% and 44.1%, respectively.Conclusion(s): Piezoelectric activation seems to improve IVF outcome in patients with previous TFF history. (Fertil Steril (R) 2010; 94: 900-4. (c) 2010 by American Society for Reproductive Medicine.)