The effect of an interrupted daily period of normal visual stimulation on form deprivation myopia in chicks
The effect of an interrupted daily period of normal visual stimulation on form deprivation myopia in chicks
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DOI：
10.1016/s0042-6989(96)00269-6
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发表时间：
1997-06-01
期刊：
影响因子：
1.8
通讯作者：
Vingrys, AJ
中科院分区：
文献类型：
--
作者：
Napper, GA;Brennan, NA;Vingrys, AJ
本研究的目的是确定神经活动的积分器是否影响由视觉剥夺引起的近视和轴向伸长的数量。将每天连续30分钟正常视力对眼部参数的影响与每次15分钟的两次暴露或每次10分钟的三次暴露进行比较。其余时间，雏鸡在12小时的光照/12小时的黑暗周期中进行单眼半透明遮挡，持续2或3周。以同伴眼和双侧未封闭雏鸡眼为对照。我们发现，在2周和3周的治疗后，每天几次短时间的正常视觉刺激比一次相同总持续时间的单次刺激更有效地预防形式剥夺性近视和轴向伸长的发展。这项研究表明，视网膜的神经活动水平可能在影响眼部生长方面具有累积效应。1997爱思唯尔科学有限公司
The aim of this study was to determine whether an integrator of neural activity influences the amount of myopia and axial elongation resulting from deprivation of form vision. The effects on ocular parameters of a continuous period of 30 min per day of normal vision was compared to two exposures of 15 min duration each, or three exposures of 10 min each. For the remaining time, chicks had monocular translucent occlusion in a 12 hr light/12 hr dark diurnal cycle, for either 2 or 3 weeks. Fellow eyes and the eyes of bilaterally unoccluded chicks were used as controls. We found that several short periods of normal visual stimulation per day were more effective in preventing the development of form deprivation myopia and axial elongation than was one single period of the same total duration, after both 2 and 3 weeks of treatment. This study suggests that the level of neural activity in the retina may have a cumulative effect in influencing ocular growth. (C) 1997 Elsevier Science Ltd.