A retrospective review on the histopathological pattern of childhood malignant solid tumors in Ethiopia.
A retrospective review on the histopathological pattern of childhood malignant solid tumors in Ethiopia.
复制标题
埃塞俄比亚儿童恶性实体瘤组织病理学模式的回顾性评价。
DOI：
10.1002/pbc.30424
复制
发表时间：
2023
影响因子：
3.2
通讯作者：
Watkins,Benjamin
中科院分区：
文献类型：
--
作者：
Ayele,RahellHailu;Yimer,YoditGetahun;Bekuretsion,Yonas;Muhe,LuluM;Patel,ShivaniA;Cunningham,SolveigA;Hailu,Daniel;Watkins,Benjamin
在低收入和中等收入国家（LMIC），由于缺乏高质量的数据，恶性肿瘤仍然报告不足。本研究概述了埃塞俄比亚最大转诊医院0-15岁儿童实体恶性肿瘤的组织病理学模式。共评估了432例实体恶性肿瘤。最常见的恶性肿瘤是淋巴瘤（21.8%）、视网膜母细胞瘤（19.4%）和肾母细胞瘤（13.9%）。伯基特淋巴瘤占2.1%，尽管在已发表文献中是撒哈拉以南非洲报告最多的儿科恶性肿瘤。在7%的病例中无法作出确诊，这与缺乏确证性检测有关。该研究强调了需要提高中低收入国家的诊断能力。
In low‐ and middle‐income countries (LMICs), malignancies remain underreported due to lack of quality data. This study outlines the histopathological pattern of pediatric solid malignancies in children aged 0–15 years at the largest referral hospital in Ethiopia. A total of 432 solid malignancies were evaluated. The most common malignancies were lymphoma (21.8%), retinoblastoma (19.4%), and Wilms tumor (13.9%). Burkitt lymphoma accounted for 2.1%, despite being the most reported pediatric malignancy in sub‐Saharan Africa in published literature. Definitive diagnosis could not be made in 7% of cases, related to the lack of confirmatory testing. The study highlights the need for improvement in diagnostic capabilities in LMICs.