BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing
BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing
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BDNF 介导的心脏微血管内皮细胞迁移在衰老过程中受损
DOI：
10.1111/j.1582-4934.2012.01621.x
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发表时间：
2012-12-01
影响因子：
5.3
通讯作者：
Cai, Dongqing
中科院分区：
文献类型：
--
作者：
Cao, Liang;Zhang, Liang;Cai, Dongqing
这项研究表明，脑源性神经营养因子（BDNF）可以通过激活BDNF-TrkB-FL-PI3K/Akt通路，促进年轻的心脏微血管内皮细胞（CMEC）迁移，这可能有利于心肌梗死（MI）后的血管生成。然而，CMECs的衰老导致受体Trk亚型的表达发生变化，在三种亚型（TrkB-FL、TrkB-T1和TrkB-T2）中，只有其中一种截短的亚型TrkB-T1继续表达，导致其配体功能障碍，CMECs迁移减少，衰老心脏损伤增加。衰老的 CMEC 中受体亚型的这种变化，加上衰老微环境的变化，可能会使衰老的心脏血管生成潜力降低，心脏病理学增加。
This study indicates that brain-derived neurotrophic factor (BDNF) can promote young cardiac microvascular endothelial cells (CMECs) to migrate via the activation of the BDNF-TrkB-FL-PI3K/Akt pathway, which may benefit angiogenesis after myocardial infarction (MI). However, the ageing of CMECs led to changes in the expression of receptor Trk isoforms in that among the three isoforms (TrkB-FL, TrkB-T1 and TrkB-T2), only one of its truncated isoforms, TrkB-T1, continued to be expressed, which leads to the dysfunction of its ligand, a decrease in the migration of CMECs and increased injury in ageing hearts. This shift in receptor isoforms in aged CMECs, together with changes in the ageing microenvironment, might predispose ageing hearts to decreased angiogenic potential and increased cardiac pathology.