Chronic exposure to dim light at night suppresses immune responses in Siberian hamsters
Chronic exposure to dim light at night suppresses immune responses in Siberian hamsters
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DOI：
10.1098/rsbl.2010.1108
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发表时间：
2011-06-23
期刊：
影响因子：
3.3
通讯作者：
Nelson, Randy J.
中科院分区：
文献类型：
--
作者：
Bedrosian, Tracy A.;Fonken, Laura K.;Nelson, Randy J.
物种已经适应了特定的生态位，优化了生存和繁殖;然而，人类的城市化极大地改变了自然栖息地。夜间人造光（LAN），被称为“光污染”，是一种经常被忽视的，但越来越多的栖息地干扰者，它扰乱了依赖于精确光信息的生理过程。例如，LAN改变了某些物种的繁殖和活动时间，这降低了成功繁殖的几率，增加了这些个体被捕食的威胁，导致适应度降低。LAN还抑制免疫功能，这是生存的重要代理。为了研究LAN在其原生栖息地中对光污染幼稚的物种中的影响，在来自野生捕获的种群的西伯利亚仓鼠中检查了免疫功能。在暴露于dim LAN四周后，评估对三种不同攻击的免疫应答：（i）迟发型超敏反应（DTH），（ii）脂多糖诱导的发热，和（iii）血液的溶血活性。LAN抑制DTH反应和脂多糖治疗后的血液中的维生素C活性降低，除了改变日常模式的运动活动，这表明人类侵占栖息地通过夜间照明可能会无意中损害免疫功能，并最终健身。
Species have been adapted to specific niches optimizing survival and reproduction; however, urbanization by humans has dramatically altered natural habitats. Artificial light at night (LAN), termed 'light pollution', is an often overlooked, yet increasing disruptor of habitats, which perturbs physiological processes that rely on precise light information. For example, LAN alters the timing of reproduction and activity in some species, which decreases the odds of successful breeding and increases the threat of predation for these individuals, leading to reduced fitness. LAN also suppresses immune function, an important proxy for survival. To investigate the impact of LAN in a species naive to light pollution in its native habitat, immune function was examined in Siberian hamsters derived from wild-caught stock. After four weeks exposure to dim LAN, immune responses to three different challenges were assessed: (i) delayed-type hypersensitivity (DTH), (ii) lipopolysaccharide-induced fever, and (iii) bactericide activity of blood. LAN suppressed DTH response and reduced bactericide activity of blood after lipopolysaccharide treatment, in addition to altering daily patterns of locomotor activity, suggesting that human encroachment on habitats via night-time lighting may inadvertently compromise immune function and ultimately fitness.