Expression of gec1/GABARAPL1 versus GABARAP mRNAs in human:: predominance of gec1/GABARAPL1 in the central nervous system
Expression of gec1/GABARAPL1 versus GABARAP mRNAs in human:: predominance of gec1/GABARAPL1 in the central nervous system
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DOI：
10.1016/j.molbrainres.2003.09.011
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发表时间：
2003-11-26
期刊：
影响因子：
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通讯作者：
Delage-Mourroux, R
中科院分区：
文献类型：
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作者：
Nemos, C;Mansuy, V;Delage-Mourroux, R
GABARAP和gec 1/GABARAPL 1基因编码非常相似的蛋白质，属于一个新的微管相关蛋白（MAP）家族。这些蛋白质可参与神经元突触后膜上GABA（A）受体的复杂聚集、靶向和/或降解。使用特异性cDNA探针，我们研究了这两个基因在76个人体组织中的差异表达。尽管如此，gec 1/GABARAPL 1在中枢神经系统（CNS）中的表达高于GABARAP，而GABARAP在内分泌腺中的表达更高。(C)2003 Elsevier B. V.保留所有权利。
GABARAP and gec1/GABARAPL1 genes encode very similar proteins belonging to a new microtubule-associated protein (MAP) family. These proteins could participate in a complex clustering, targeting and/or degrading the GABA(A) receptors on post-synaptic membrane of neurons. Using specific cDNA probes, we investigated the differential expression of both genes in 76 human tissues. Against all odds, gec1/ GABARAPL1 was more expressed than GABARAP in the central nervous system (CNS), while GABARAP was more expressed in endocrine glands. (C) 2003 Elsevier B.V. All rights reserved.