n-3 fatty acids and gene expression
n-3 fatty acids and gene expression
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DOI：
10.1093/ajcn/83.6.1520s
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发表时间：
2006-06-01
影响因子：
7.1
通讯作者：
Seo, Toru
中科院分区：
文献类型：
--
作者：
Deckelbaum, Richard J.;Worgall, Tilla S.;Seo, Toru
在人类和动物模型中积累的证据清楚地表明，一组极长链多不饱和脂肪酸，n-3脂肪酸（或omega-3），与其他脂肪酸组相比具有独特和重要的生物活性。已知脂肪酸可以降低与多种疾病相关的许多风险因素，如心血管疾病，糖尿病和癌症。n-3脂肪酸影响基因表达的机制是复杂的，涉及多个过程。例如，n-3脂肪酸调节2组转录因子，如固醇调节元件结合蛋白和过氧化物酶体增殖物激活受体，它们对于调节控制全身和组织特异性脂质稳态的基因的表达至关重要。n-3脂肪酸对特定基因的调节和这些基因之间的相互作用是n-3脂肪酸的许多作用的原因。
Accumulating evidence in both humans and animal models clearly indicates that a group of very-long-chain polyunsaturated fatty acids, the n-3 fatty acids (or omega-3), have distinct and important bioactive properties compared with other groups of fatty acids. n-3 Fatty acids are known to reduce many risk factors associated with several diseases, such as cardiovascular diseases, diabetes, and cancer. The mechanisms whereby n-3 fatty acids affect gene expression are complex and involve multiple processes. As examples, n-3 fatty acids regulate 2 groups of transcription factors, such as sterol-regulatory-element binding proteins and peroxisome proliferator-activated receptors, that are critical for modulating the expression of genes controlling both systemic and tissue-specific lipid homeostasis. Modulation of specific genes by n-3 fatty acids and cross-talk between these genes are responsible for many effects of n-3 fatty acids.