Responses of non-eye-movement central vestibular neurons to sinusoidal yaw rotation in compensated macaques after unilateral semicircular canal plugging.
Responses of non-eye-movement central vestibular neurons to sinusoidal yaw rotation in compensated macaques after unilateral semicircular canal plugging.
复制标题
单侧半规管堵塞后代偿猕猴中非眼动中央前庭神经元对正弦偏航旋转的反应。
DOI：
10.1152/jn.00212.2016
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发表时间：
2016
影响因子：
2.5
通讯作者：
Luan,Hongge
中科院分区：
文献类型：
--
作者：
Newlands,ShawnD;Wei,Min;Morgan,David;Luan,Hongge
前庭迷路损伤后，前庭功能行为学指标有不同程度的恢复（前庭代偿）。单侧迷路切除术（UL）后的中枢神经元反应，消除了传入静息活动和运动敏感性，已经得到了很好的研究。然而，单侧半圆管堵塞（UCP）在保持传入静息活动完整的同时减弱了角速度检测，尚未得到广泛的研究。本研究报道了UCP代偿后，猕猴前庭神经元对偏敏非眼动的反应特性。比较UCP前和UCP后至少6周记录的神经元在一系列频率（0.1-2 Hz）和峰值速度（15-210°/s）下的反应。0.5 Hz，±60°/s（0.48±0.30 (SD) normal, 0.32±0.15 ipsilsion）时，UCP侧中央I型神经元（对同侧偏航旋转作出反应）的增益（sp/s/°/s）相对于正常对照组降低；[0.44±0.2]。UCP后II型神经元（对侧偏航旋转响应）增益降低（0.40±0.27正常，0.35±0.25异向，0.25±0.18异向）。UCP后和UL后反应的差异主要在于I型和II型神经元在前庭核中的分布（I型神经元在正常前庭核中占66%，单发UCP占51%，单发UCP占59%，单发UL占38%，单发UL占65%）以及II型神经元在病变同侧的反应程度。这些差异表明，与UCP相比，需要补偿UL后静息前庭神经活动的单侧丧失，需要采用不同的策略来恢复动态前庭反应。
After vestibular labyrinth injury, behavioral measures of vestibular performance recover to variable degrees (vestibular compensation). Central neuronal responses after unilateral labyrinthectomy (UL), which eliminates both afferent resting activity and sensitivity to movement, have been well-studied. However, unilateral semicircular canal plugging (UCP), which attenuates angular-velocity detection while leaving afferent resting activity intact, has not been extensively studied. The current study reports response properties of yaw-sensitive non-eye-movement rhesus macaque vestibular neurons after compensation from UCP. The responses at a series of frequencies (0.1–2 Hz) and peak velocities (15–210°/s) were compared between neurons recorded before and at least 6 wk after UCP. The gain (sp/s/°/s) of central type I neurons (responding to ipsilateral yaw rotation) on the side of UCP was reduced relative to normal controls at 0.5 Hz, ±60°/s [0.48 ± 0.30 (SD) normal, 0.32 ± 0.15 ipsilesion; 0.44 ± 0.2 contralesion]. Type II neurons (responding to contralateral yaw rotation) after UCP have reduced gain (0.40 ± 0.27 normal, 0.35 ± 0.25 ipsilesion; 0.25 ± 0.18 contralesion). The difference between responses after UCP and after UL is primarily the distribution of type I and type II neurons in the vestibular nuclei (type I neurons comprise 66% in vestibular nuclei normally; 51% ipsilesion UCP; 59% contralesion UCP; 38% ipsilesion UL; 65% contralesion UL) and the magnitude of the responses of type II neurons ipsilateral to the lesion. These differences suggest that the need to compensate for unilateral loss of resting vestibular nerve activity after UL necessitates a different strategy for recovery of dynamic vestibular responses compared to after UCP.