Adopting moderate alcohol consumption in middle age: Subsequent cardiovascular events
Adopting moderate alcohol consumption in middle age: Subsequent cardiovascular events
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DOI：
10.1016/j.amjmed.2007.12.004
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发表时间：
2008-03-01
影响因子：
5.9
通讯作者：
Geesey, Mark E.
中科院分区：
文献类型：
--
作者：
King, Dana E.;Mainous, Arch G., III;Geesey, Mark E.
目得：适度饮酒是健康生活方式的一部分，但目前的指南警告不饮酒者不要在中年开始饮酒。本研究的目的是评估是否采取适度饮酒在中年将导致随后较低的心血管risk.METHODS：本研究探讨了一个队列的年龄在45-64岁的成年人参与动脉粥样硬化风险在社区研究超过10年的时间。主要结果是致命或非致命的心血管事件。结果：7697名参与者没有心血管疾病史，基线时不饮酒，在6年的随访期内，6.0%开始适度饮酒（男性每天2杯或更少，女性每天1杯或更少），0.4%开始大量饮酒。经过4年的随访，新的适度饮酒者患心血管疾病的几率比持续不饮酒的人低38%。在调整人口统计学和心血管危险因素后，这种差异仍然存在（比值比0.62，95%置信区间，0.40-0.95）。新饮酒者和持续不饮酒者之间的全因死亡率没有差异（比值比0.71，95%置信区间，0.31-1.64）。结论：新开始饮酒的人在中年很少超过推荐量。那些开始适度饮酒的人经历了相对迅速的心血管疾病发病率降低的好处，4年后死亡率没有变化。(C)2008年爱思唯尔公司All rights reserved.
PURPOSE: Moderate alcohol use is part of a healthy lifestyle, yet current guidelines caution nondrinkers against starting to drink alcohol in middle age. The purpose of this study was to evaluate whether adopting moderate alcohol consumption in middle age would result in subsequent lower cardiovascular risk.METHODS: This study examined a cohort of adults aged 45-64 years participating in the Atherosclerosis Risk in Communities study over a 10-year period. The primary outcome was fatal or nonfatal cardiovascular events.RESULTS: Of 7697 participants who had no history of cardiovascular disease and were nondrinkers at baseline, within a 6-year follow-up period, 6.0% began moderate alcohol consumption (2 drinks per day or fewer for men, 1 drink per day or fewer for women) and 0.4% began heavier drinking. After 4 years of follow-up, new moderate drinkers had a 38% lower chance of developing cardiovascular disease than did their persistently nondrinking counterparts. This difference persisted after adjustment for demographic and cardiovascular risk factors (odds ratio 0.62, 95% confidence interval, 0.40-0.95). There was no difference in all-cause mortality between the new drinkers and persistent nondrinkers (odds ratio 0.71, 95% confidence interval, 0.31-1.64).CONCLUSION: People who newly begin consuming alcohol in middle age rarely do so beyond recommended amounts. Those who begin drinking moderately experience a relatively prompt benefit of lower rates of cardiovascular disease morbidity with no change in mortality rates after 4 years. (C) 2008 Elsevier Inc. All rights reserved.