Antimicrobial Human β-Defensins in the Colon and Their Role in Infectious and Non-Infectious Diseases.
Antimicrobial Human β-Defensins in the Colon and Their Role in Infectious and Non-Infectious Diseases.
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DOI：
10.3390/pathogens2010177
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发表时间：
2013-03-19
期刊：
影响因子：
--
通讯作者：
Chadee K
中科院分区：
文献类型：
--
作者：
Cobo ER;Chadee K
β-防御素是由包括结肠上皮细胞在内的多种细胞分泌的小分子阳离子抗菌肽。人β-防御素形成先天免疫中肠腔的必需组分。β-防御素的防御机制包括与带负电荷的微生物膜结合，导致细胞死亡和免疫细胞的化学吸引。β-防御素的抗微生物活性在体外针对几种肠道病原体和在非感染性过程如炎性肠病中被充分报道，这改变了β-防御素的产生。然而，β-防御素在体内与其他免疫组分在宿主防御具有更复杂膜的细菌、病毒和寄生虫中的相互作用中的作用仍然不为人所知。本文就β-防御素在人类感染性和非感染性结肠黏膜疾病中的作用作一综述。此外，我们总结了β-防御素的最重要的方面和它在各种疾病过程中的抗菌作用。
β-defensins are small cationic antimicrobial peptides secreted by diverse cell types including colonic epithelial cells. Human β-defensins form an essential component of the intestinal lumen in innate immunity. The defensive mechanisms of β-defensins include binding to negatively charged microbial membranes that cause cell death and chemoattraction of immune cells. The antimicrobial activity of β-defensin is well reported in vitro against several enteric pathogens and in non-infectious processes such as inflammatory bowel diseases, which alters β-defensin production. However, the role of β-defensin in vivo in its interaction with other immune components in host defense against bacteria, viruses and parasites with more complex membranes is still not well known. This review focuses on the latest findings regarding the role of β-defensin in relevant human infectious and non-infectious diseases of the colonic mucosa. In addition, we summarize the most significant aspects of β-defensin and its antimicrobial role in a variety of disease processes.
DOI：
10.1084/jem.193.9.f31
发表时间：
2001-05-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ganz T
通讯作者：
Ganz T