Long-term curcumin treatment antagonizes masseter muscle alterations induced by chronic unpredictable mild stress in rats
Long-term curcumin treatment antagonizes masseter muscle alterations induced by chronic unpredictable mild stress in rats
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长期姜黄素治疗可拮抗大鼠慢性不可预测的轻度应激引起的咬肌改变
DOI：
10.1016/j.archoralbio.2013.12.001
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发表时间：
2014-03-01
影响因子：
3
通讯作者：
Chen, Yong-Jin
中科院分区：
文献类型：
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作者：
Cui, Min;Li, Qiang;Chen, Yong-Jin
目的：为探讨心理应激与咬肌损伤的相关性，探索修复受损咀嚼肌的治疗药物，建立慢性不可预知轻度应激（GUMS）动物模型，观察姜黄素治疗前后大鼠咬肌超微结构、氧化还原稳态和能量代谢的变化。蔗糖偏好实验和旷场实验均显示应激大鼠出现抑郁样行为，而姜黄素可缓解上述现象。除超微结构的病理改变外，应激大鼠MM还可出现SOD、GSH-Px、CAT、Na+-K（+）ATP酶、Ca 2 +-Mg 2 + ATP酶活性降低，MDA、LD含量和LDH活性升高。然而，姜黄素能够通过改善所检查的抗氧化酶和能量代谢酶的活性来逆转GUMS诱导的MM病症。此外，增加的MDA含量，LD含量，LDH活性在应激大鼠减少姜黄素。结论：所有的研究结果表明，GUMS对MM功能在大鼠的不利影响，并提高姜黄素作为一个潜在的治疗剂心理应激引起的咬肌功能障碍的可能性。(C)2013爱思唯尔有限公司保留所有权利。
Objective: To investigate the correlation between psychological stress and masseter muscle (MM) alterations, and explore the therapeutic agents for restoring the impaired masticatory muscle.Design: We established a chronic unpredictable mild stress (GUMS) animal model and observed the changes of ultrastructure, redox homeostasis and energy metabolism in MM in rats with and without curcumin treatment.Results: The depressive-like behavior in stressed rats was confirmed by the evidences of altered behaviors in sucrose preference test and open field test; while these phenomena were eased by curcumin. Except for the pathological changes in ultrastructure, decreased SOD, GSH-Px, CAT, Na+-K(+)ATPase, and Ca2+-Mg2+ ATPase activities as well as increased MDA and LD content and LDH activity were also observed in MM in stressed rats. However, curcumin was capable of reversing GUMS-induced MM disorder by improving the activities of the examined anti-oxidant enzymes and energy metabolism enzymes. Additionally, the increased MDA content, LD content, and LDH activity in stressed rats were reduced by curcumin.Conclusion: All the findings indicate the adverse effects of GUMS on MM function in rats, and raise the possibility of developing curcumin as a potential therapeutic agent for psychological stress-induced masseter dysfunction. (C) 2013 Elsevier Ltd. All rights reserved.