TNF-α-308 and INF-γ+874 Gene Polymorphisms in Relation to Susceptibility and Severity of Type 2 Diabetes Mellitus among Egyptian patients
TNF-α-308 and INF-γ+874 Gene Polymorphisms in Relation to Susceptibility and Severity of Type 2 Diabetes Mellitus among Egyptian patients
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埃及患者 TNF-α-308 和 INF-γ+874 基因多态性与 2 型糖尿病易感性和严重程度的关系
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
A. Settin
中科院分区：
文献类型：
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作者：
A. Elsaid;M. Helaly;El;O. Fouda;A. Settin
To explore the association of TNF-α-308 and IFN- γ +874 genetic polymorphisms with type 2 diabetes mellitus (DM) in Egyptian cases. Participants included 207 cases with type 2 DM, 93 males and 114 females. Their mean age was 57 years. They were compared to a control group of 212 healthy unrelated subjects from the same locality. DNA was amplified using PCR with sequence specific primers for detection of polymorphism related to TNF-α-308 (G/A) and IFN-γ+874 (A/T). The combined homozygote pat tern of TNF-α-308 (AA) and IFN-γ+874 (A/A) was significantly higher in diabetic cases versus controls (p=0.023) that was manifest (although non-significant) among complicated, uncontrolled cases and cases with marked insulin resistance. Polymorphism related to TNF-α-308 AA and IFN-γ+874 AA may be considered as a genetic biomarker for type 2 DM in Egyptian subjects with potential impact on family counseling and management.
