Can Red Cell Distribution Width Help to Discriminate Benign from Malignant Biliary Obstruction? A Retrospective Single Center Analysis
Can Red Cell Distribution Width Help to Discriminate Benign from Malignant Biliary Obstruction? A Retrospective Single Center Analysis
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DOI：
10.5754/hge10676
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发表时间：
2012-07-01
影响因子：
--
通讯作者：
Arhan, Mehmet
中科院分区：
文献类型：
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作者：
Beyazit, Yavuz;Kekilli, Murat;Arhan, Mehmet
背景/目标：良性梗阻性黄疸与恶性梗阻性黄疸的鉴别仍然很困难，尽管诊断方法有所改进。本研究旨在评价红细胞分布宽度（RDW）在鉴别梗阻性黄疸良恶性病因中的作用。方法学：在2008年1月至2009年8月期间，回顾了194例有梗阻性黄疸病史的连续患者（101例恶性，93例良性）。胆管狭窄的定义由胆管造影特征提出，并由刷检细胞学、细针穿刺（FNA）和成像和/或临床随访的肿块或转移的存在支持。根据出院诊断将患者分为良性和恶性两组。结果如下：受试者工作特征分析显示，RDW为14.8%是预测恶性胆管狭窄的最佳截断值，其敏感性为72%，特异性为69%（AUC=0.755，95% CI=0.649-0.810）。RDW增加（>14.8%）在良性肿瘤和恶性肿瘤中分别为31.6%和68.4%。低RDW水平（
Background/Aims: Differentiation of benign obstructive jaundice from malignant obstructive jaundice still remains difficult, despite improvements in diagnostic modalities. The aim of this study is to evaluate the usefulness of red cell distribution width (RDW) in differentiating benign and malignant causes of obstructive jaundice. Methodology: One hundred and ninety four consecutive patients (101 malignant, 93 benign) with a history of obstructive jaundice were reviewed in the period between January 2008 and August 2009. Definition of biliary strictures was suggested by cholangiographic features and supported by brush cytology, fine needle aspiration (FNA) and the presence of mass or metastases by imaging and/or clinical follow-up. Patients were divided into two groups, benign and malignant, based on the discharge diagnosis. Results: The receiver operating characteristic analysis showed that a RDW of 14.8% was the best cut-off value for predicting a malignant biliary stricture with a sensitivity of 72% and a specificity of 69% (AUC=0.755, 95% CI=0.649-0.810). RDW was increased (>14.8%) in 31.6% of benign cases and 68.4% of malignancies. Depressed RDW levels (