Fabrication of functional PLGA-based electrospun scaffolds and their applications in biomedical engineering
Fabrication of functional PLGA-based electrospun scaffolds and their applications in biomedical engineering
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功能性PLGA电纺支架的制备及其在生物医学工程中的应用
DOI：
10.1016/j.msec.2015.11.026
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发表时间：
2016-02-01
影响因子：
7.9
通讯作者：
Li, Chenrui
中科院分区：
文献类型：
--
作者：
Zhao, Wen;Li, Jiaojiao;Li, Chenrui
电纺PLGA支架在生物医学工程中有着广泛的应用，如组织工程、药物缓释系统等。PLGA纤维支架由于缺乏细胞识别位点、亲水性、功能单一等原因，限制了其应用。为了解决这些问题，人们做了许多工作来获得功能性的PLGA基支架，包括表面改性、PLGA基复合支架的制备和载药支架。基于PLGA的功能性支架具有显著改善的细胞粘附、附着和增殖。综述了PLGA基功能性支架材料在伤口敷料、血管和骨组织工程以及药物缓释系统中的应用。(C)2015 Elsevier B.V.版权所有。
Electrospun PLGA-based scaffolds have been applied extensively in biomedical engineering, such as tissue engineering and drug delivery system. Due to lack of the recognition sites on cells, hydropholicity and single-function, the applications of PLGA fibrous scaffolds are limited. In order to tackle these issues, many works have been done to obtain functional PLGA-based scaffolds, including surface modifications, the fabrication of PLGA-based composite scaffolds and drug-loaded scaffolds. The functional PLGA-based scaffolds have significantly improved cell adhesion, attachment and proliferation. Moreover, the current study has summarized the applications of functional PLGA-based scaffolds in wound dressing, vascular and bone tissue engineering area as well as drug delivery system. (C) 2015 Elsevier B.V. All rights reserved.