Autophagic degradation of focal adhesions underlies metastatic cancer dissemination.
Autophagic degradation of focal adhesions underlies metastatic cancer dissemination.
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粘着斑的自噬降解是转移性癌症扩散的基础。
DOI：
10.1080/23723556.2016.1198299
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发表时间：
2017
影响因子：
2.1
通讯作者：
Macleod,KayF
中科院分区：
文献类型：
--
作者：
Sharifi,MarinaN;Mowers,ErinE;Macleod,KayF
自噬抑制正在被评估为多种肿瘤类型的一种新的治疗策略，但对其转移传播的影响知之甚少。我们最近报道，通过与自噬蛋白LC3B的直接相互作用，paxillin的自噬降解是局灶黏附分解、src刺激的肿瘤细胞运动和转移所必需的。
Autophagy inhibition is being evaluated as a novel therapeutic strategy in multiple tumor types, but little is known about its implications for metastatic dissemination. We recently reported that autophagic degradation of paxillin through direct interaction with the autophagy protein LC3B is required for focal adhesion disassembly, Src-stimulated tumor cell motility, and metastasis.