Salmonella Susceptibility
Salmonella Susceptibility
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DOI：
10.1126/science.1189088
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发表时间：
2010-04
期刊：
影响因子：
56.9
通讯作者：
S. Moir;A. Fauci
中科院分区：
文献类型：
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作者：
S. Moir;A. Fauci
HIV感染者产生沙门氏菌抗体，阻断保护性抗体的作用。非伤寒沙门氏菌（NTS）是一组肠道细菌，在健康个体中引起自限性胃肠炎，但在免疫系统减弱的人中可导致危及生命的菌血症。在1995-1996年引入高效抗逆转录病毒疗法之前，NTS菌血症是与HIV感染相关的常见机会致病菌（1）。今天，在抗逆转录病毒治疗有限的国家，NTS仍然是HIV感染者发病和死亡的重要原因（2）。在本期的第508页，MacLennan等人确定了一种免疫反应，这种免疫反应允许NTS在感染HIV的个体中茁壮成长，从而导致对NTS感染的正常免疫反应有缺陷（3）。这可能对开发针对NTS的疫苗具有重要意义。
HIV-infected individuals produce antibodies to Salmonella that block the effects of protective antibodies. Nontyphoidal Salmonella (NTS) are a group of enteric bacteria that cause self-limiting gastroenteritis in healthy individuals but can lead to life-threatening bacteremia in those with weakened immune systems. Before the introduction of highly effective antiretroviral therapy in 1995–1996, NTS bacteremia was a common opportunistic pathogen associated with HIV infection (1). Today, in countries with limited availability of antiretroviral therapy, NTS remains an important cause of morbidity and mortality in HIV-infected individuals (2). On page 508 of this issue, MacLennan et al. identify an immune response that allows NTS to thrive in individuals infected with HIV, thus causing the normal immune reaction to NTS infection to be defective (3). This may have important implications for the development of a vaccine against NTS.