Targeted Tuning of Interactive Forces by Engineering of Molecular Bonds in Series and Parallel Using Peptide-Based Adhesives.
Targeted Tuning of Interactive Forces by Engineering of Molecular Bonds in Series and Parallel Using Peptide-Based Adhesives.
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通过使用肽基粘合剂对串联和并联分子键进行工程设计，有针对性地调节相互作用力
DOI：
10.1021/acs.langmuir.5b02746
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Valtiner
中科院分区：
文献类型：
--
作者：
Valtiner
聚合物介导的粘附在技术胶水和自组装或生物识别等生物过程中起着重要作用。与工程系统相比，生物系统中的粘附强度是通过单个键的良好调整安排来精确调节的。然而，如何通过单个键的排列来设计附着力还没有得到很好的理解。在这里，我们展示了如何通过特别设计的表面桥接肽来显著影响串联和并联键的数量。我们直接测量了- COOH和- nh2功能化表面之间的附着力如何随平行键数的变化而变化。我们还介绍了表面桥接肽序列，类似的末端功能化与胺和羧酸。与单分子连接相比，由这些表面桥接肽介导的粘合强度在由两个酸/碱键串联组成的粘合连接中降低了2倍。此外，粘接强度随键密度平行变化。对于致密系统，我们观察到桥接肽单层的形成受到立体阻碍，因此粘附力进一步显著降低了20%。我们的研究结果揭示了单个键在粘合结中的排列如何允许在仅利用单个特定键的基础上广泛调整粘合强度。因此，对于肽粘合剂来说，在广泛的应用中并行考虑键是至关重要的，在这些应用中，高粘附性和触发释放粘合键是必不可少的。
Polymer-mediated adhesion plays a major role for both technical glues and biological processes like self-assembly or biorecognition. In contrast to engineering systems, adhesive strength in biological systems is precisely tuned via well-adjusted arrangement of individual bonds. How adhesion may be engineered by arrangement of individual bonds is however not yet well-understood. Here we show how the number of bonds in series and parallel can significantly influence adhesion forces using specifically designed surface-bridging peptides. We directly measure how adhesion forces between −COOH and −NH2functionalized surfaces across aqueous media vary as a function of the number of bonds in parallel. We also introduce surface bridging peptide sequences that are similarly end-functionalized with amines and carboxylic acid. Compared to single molecular junctions, adhesive strength mediated by these surface bridging peptides decreases by a factor of 2 for adhesive junctions that consist of two acid/base bonds in series. Furthermore, adhesive strength varies with the density of bonds in parallel. For dense systems, we observe that the formation of a bridging peptide monolayer is sterically hindered and therefore adhesion is further reduced significantly by 20%. Our results unravel how the arrangement of individual bonds in an adhesive junction allows for a wide tuning of adhesive strength on the basis of utilizing just one single specific bond. As such, for peptide adhesives it is essential to consider bonds in parallel in a wide range of applications where both high adhesion and triggered release of adhesive bonds is essential.
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影响因子：
3.4
作者：
Evans, E;Ritchie, K
通讯作者：
Ritchie, K
影响因子：
3.4
作者：
LECKBAND, D;MULLER, W;RINGSDORF, H
通讯作者：
RINGSDORF, H
由串联键介导的粘附力
DOI：
--
发表时间：
1996
期刊：
Biotechnology progress (Print)
影响因子：
--
作者：
A. Saterbak;D. Lauffenburger
通讯作者：
D. Lauffenburger
影响因子：
16.6
作者：
Raman, Sangeetha;Utzig, Thomas;Valtiner, Markus
通讯作者：
Valtiner, Markus
影响因子：
3.9
作者：
Utzig, Thomas;Raman, Sangeetha;Valtiner, Markus
通讯作者：
Valtiner, Markus