Chordoid glioma in suprasellar location with extension into the third ventricle: Smear preparation morphology of a rare tumor
Chordoid glioma in suprasellar location with extension into the third ventricle: Smear preparation morphology of a rare tumor
复制标题
鞍上位置的脊索样神经胶质瘤延伸至第三脑室：罕见肿瘤的涂片制备形态
DOI：
10.1002/dc.21606
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发表时间：
2012
影响因子：
1.3
通讯作者：
A. Hegde
中科院分区：
文献类型：
--
作者：
N. Ghosal;Sumit Thakar;S. Kumaran;A. Hegde
我们报告一例罕见的复发性脊索样胶质瘤在鞍上区延伸到第三脑室术前诊断。在MRI上，发现鞍上区有一个2.5 × 3 × 3.5 cm的强烈对比增强病变，向上延伸到第三脑室。患者8个月前曾接受过肿瘤次全切除术，并接受了56戈伊的术后放疗。涂片显示肿瘤细胞排列成弦状和行状，呈粘液样，淋巴细胞散在分布。单个细胞呈多边形，有中等数量的淡嗜酸性细胞质，少数细胞有胞浆空泡。细胞核染色质细，核仁小而突出。石蜡切片证实了诊断，在免疫组织化学上，肿瘤细胞显示GFAP强阳性和EMA局灶性弱阳性，MIB-1标记指数低（<1%）。据我们所知，这是第一个记录在案的情况下，脊索样胶质瘤描述的挤压细胞学。细胞病理学诊断。2012; © 2011 Wiley Periodicals，Inc.
We report a rare case of recurrent chordoid glioma in suprasellar region with extension into the third ventricle diagnosed peroperatively. On MRI, a brilliantly contrast enhancing lesion in the suprasellar region extending superiorly into the third ventricle and measuring 2.5 × 3 × 3.5 cm was identified. Patient had a previous history of subtotal removal of the tumor 8 months back and had received 56 Gy of postoperative radiotherapy. On smear preparation the tumor was composed of cells arranged in chords and rows in a myxoid background with sprinkling of lymphocytes. The individual cells were polygonal with moderate amount of faintly eosinophilic cytoplasm with cytoplasmic vacoules in few cells. The nuclei showed fine chromatin with small prominent nucleoli. Paraffin sections confirmed the diagnosis and on immunohistochemistry the tumor cells showed strong positivity for GFAP and focal weak positivity for EMA with low MIB‐1 labeling index (<1%). To the best of our knowledge this is the first documented case of chordoid glioma described on crush cytology. Diagn. Cytopathol. 2012; © 2011 Wiley Periodicals, Inc.