The successful combination of grapefruit juice and venetoclax in an unfit acute myeloid leukemia patient with adverse risk: A case report.
The successful combination of grapefruit juice and venetoclax in an unfit acute myeloid leukemia patient with adverse risk: A case report.
复制标题
葡萄柚汁和维奈托克的成功组合治疗一名患有不良风险的不健康的急性髓性白血病患者：病例报告
DOI：
10.3389/fonc.2022.912696
复制
发表时间：
2022
影响因子：
4.7
通讯作者：
Huang, Zhengqi
中科院分区：
文献类型：
--
作者：
Long, Zhangbiao;Ruan, Min;Wu, Wei;Zeng, Qingshu;Li, Qingsheng;Huang, Zhengqi
Venetoclax联合低甲基化药物如阿扎胞苷和地西他滨是不适合强化诱导治疗的老年急性髓性白血病（AML）患者的标准方案。然而，由于venetoclax的高昂费用，许多患者因经济困难而放弃治疗。在这项研究中，我们使用阿扎胞苷、低剂量venetoclax和葡萄柚汁治疗一名TP53突变的AML患者。同时监测了维妥拉克斯的峰值浓度（Cmax）和对患者的副作用。患者在有效浓度范围（1000 - 3000 ng/ml）内使用venetoclax Cmax获得完全缓解，并保持持续缓解，直到最近。第一周期出现发热性中性粒细胞减少症、血小板减少症和肺炎，经刺激药物和抗生素治疗后恢复。这种药物-食物相互作用的改善联合方法可能会给其他类似的AML患者，特别是中低收入国家的患者带来启发。
Venetoclax combined with hypomethylating agents such as azacitidine and decitabine is the standard regime for the elderly patient with acute myeloid leukemia (AML) unfit for intensive induction therapy. However, many patients struggle with finances and forgo treatments due to the high costs of venetoclax. In this study, we performed the regime with azacitidine, low-dose venetoclax, and grapefruit juice on an unfit AML patient with TP53 mutation. The peak venetoclax concentration (Cmax) and side effects on the patient were also monitored. The patient achieved complete remission with the venetoclax Cmax within the effective concentration range (1,000–3,000 ng/ml) and maintained durable remission until recently. Febrile neutropenia, thrombocytopenia, and pneumonia appeared during the first cycle and were recovered by stimulating agents and antibiotic treatment. This improvement combination approach by drug-food interaction may enlighten other similarly patients with AML, especially those in low-middle income countries.
登录
查看更多内容
影响因子：
3.6
作者：
Chen, Meng;Zhou, Shu-yi;Fabriaga, Erlinda;Zhang, Pian-hong;Zhou, Quan
通讯作者：
Zhou, Quan
影响因子：
7.5
作者：
Patel, Kishan K.;Zeidan, Amer M.;Huntington, Scott F.
通讯作者：
Huntington, Scott F.
影响因子：
2.9
作者：
Salem, Ahmed Hamed;Agarwal, Suresh K.;Wong, Shekman L.
通讯作者：
Wong, Shekman L.
影响因子：
2.6
作者：
Graveno, Molly E.;Carulli, Alison;Pratz, Keith W.
通讯作者：
Pratz, Keith W.
影响因子：
3.2
作者：
Agarwal, Suresh K.;DiNardo, Courtney D.;Salem, Ahmed Hamed
通讯作者：
Salem, Ahmed Hamed