THE EFFECTS OF LESIONS IN THE HYPOTHALAMUS IN PARABIOTIC RATS
THE EFFECTS OF LESIONS IN THE HYPOTHALAMUS IN PARABIOTIC RATS
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DOI：
10.1113/jphysiol.1959.sp006145
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发表时间：
1959-01-01
影响因子：
5.5
通讯作者：
HERVEY, GR
中科院分区：
文献类型：
--
作者：
HERVEY, GR
在大鼠的下丘脑中产生病变，所述大鼠是在联体生活中成对连接的成员，通过肌肉和腹膜的4个切割边缘的单次缝合来完成连接。下丘脑病变的动物表现出明显的暴食和肥胖。下丘脑正常的联体伴侣变瘦。随后的病变产生在下丘脑的合作伙伴时，薄引起暴食。这表明，下丘脑正常的伴侣变瘦是因为他们吃得少;这反过来又是由于他们的下丘脑控制中心对手术动物的过度喂养的反应。有三种理论可以解释这种下丘脑反应：体内储存的脂肪量，动脉和静脉血液中葡萄糖水平的差异，以及进食引起的温度上升到一定水平。在这种情况下，数据往往指向“储存脂肪”理论和一些扩散相关的代谢物。
Lesions were produced in the hypothalami of rats which were members of pairs joined in parabiosis, the union being accomplished by a single suture of 4 cut edges of muscle and peritoneum. The animals with hypothalamic lesions displayed marked hyper-phagia and obesity. The parabiotic partners with normal hypothalami became thin. Subsequent lesions produced in the hypothalami of 2 of the partners when thin caused hyperphagia. It is suggested that the partners with normal hypothalami became thin because they ate less; and that this in turn was due to a response on the part of their hypothalamic controlling centers to the operated animals'' overfeeding. Three theories were cited which might explain this hypothalamic response: amount of stored fat in the body, difference in the arterial and venous blood levels of glucose, and a rise in temperature to a certain level caused by eating. The data in this instance tend to point toward the "stored fat" theory and some diffusible associated metabolite.