Two-dose COVID-19 vaccination and possible arthritis flare among patients with rheumatoid arthritis in Hong Kong.
Two-dose COVID-19 vaccination and possible arthritis flare among patients with rheumatoid arthritis in Hong Kong.
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香港类风湿关节炎患者中的两剂共证于19号疫苗接种和可能的关节炎炎症。
DOI：
10.1136/annrheumdis-2021-221571
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发表时间：
2022-04
影响因子：
27.4
通讯作者：
Wong ICK
中科院分区：
文献类型：
--
作者：
Li X;Tong X;Yeung WWY;Kuan P;Yum SHH;Chui CSL;Lai FTT;Wan EYF;Wong CKH;Chan EWY;Lau CS;Wong ICK
研究COVID-19全面疫苗接种（两次完整剂量）与可能的关节炎发作之间的关系。类风湿性关节炎（RA）患者是从具有疫苗接种关联的基于人群的电子病历中识别出来的，并分为BNT 162 b2（mRNA疫苗）、CoronaVac（灭活病毒疫苗）和未接种疫苗组。使用倾向加权队列研究设计比较接种疫苗后可能发生关节炎发作的风险。根据发作期间的诊断记录，我们将可能的关节炎发作定义为与RA或反应性关节炎相关的住院和门诊咨询。我们比较了自COVID-19疫苗接种计划启动以来每周的风湿病药物处方，以补充基于诊断的分析结果。5493例RA患者中（BNT 162 b2：653; CoronaVac：671;未接种疫苗：4169），倾向评分加权泊松回归显示关节炎发作与COVID-19疫苗接种之间无显著相关性（（BNT 162 b2：调整后的发生率比0.86，95%置信区间0.73 - 1.01）; CoronaVac：0.87（0.74 - 1.02））。自启动大规模疫苗接种计划以来，每周风湿性药物处方的分布在三组之间没有显着差异（Kruskal-Wallis检验的所有p值>0.1）。目前的证据并不支持mRNA或灭活病毒COVID-19疫苗的全面接种与可能的关节炎发作相关。
To investigate the relationship between COVID-19 full vaccination (two completed doses) and possible arthritis flare. Patients with rheumatoid arthritis (RA) were identified from population-based electronic medical records with vaccination linkage and categorised into BNT162b2 (mRNA vaccine), CoronaVac (inactive virus vaccine) and non-vaccinated groups. The risk of possible arthritis flare after vaccination was compared using a propensity-weighted cohort study design. We defined possible arthritis flare as hospitalisation and outpatient consultation related to RA or reactive arthritis, based on diagnosis records during the episode. Weekly prescriptions of rheumatic drugs since the launch of COVID-19 vaccination programme were compared to complement the findings from a diagnosis-based analysis. Among 5493 patients with RA (BNT162b2: 653; CoronaVac: 671; non-vaccinated: 4169), propensity-scored weighted Poisson regression showed no significant association between arthritis flare and COVID-19 vaccination ((BNT162b2: adjusted incidence rate ratio 0.86, 95% Confidence Interval 0.73 to 1.01); CoronaVac: 0.87 (0.74 to 1.02)). The distribution of weekly rheumatic drug prescriptions showed no significant differences among the three groups since the launch of the mass vaccination programme (all p values >0.1 from Kruskal-Wallis test). Current evidence does not support that full vaccination of mRNA or inactivated virus COVID-19 vaccines is associated with possible arthritis flare.
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DOI：
10.1016/s1473-3099(21)00451-5
发表时间：
2022-01
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Wan EYF;Chui CSL;Lai FTT;Chan EWY;Li X;Yan VKC;Gao L;Yu Q;Lam ICH;Chun RKC;Cowling BJ;Fong WC;Lau AYL;Mok VCT;Chan FLF;Lee CK;Chan LST;Lo D;Lau KK;Hung IFN;Leung GM;Wong ICK
通讯作者：
Wong ICK
影响因子：
2
作者：
Austin, Peter C.
通讯作者：
Austin, Peter C.
DOI：
10.1016/s2665-9913(21)00108-9
发表时间：
2021-07
期刊：
The Lancet. Rheumatology
影响因子：
--
作者：
Terracina KA;Tan FK
通讯作者：
Tan FK
影响因子：
25.8
作者：
Man, Kenneth K. C.;Coghill, David;Wong, Ian C. K.
通讯作者：
Wong, Ian C. K.
影响因子：
120.7
作者：
Lau, Wallis C. Y.;Chan, Esther W.;Wong, Ian C. K.
通讯作者：
Wong, Ian C. K.