The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury.
The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury.
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Claudin 14 在坐骨神经损伤后早期华勒变性中的作用
DOI：
10.4103/1673-5374.147946
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发表时间：
2014-12-15
影响因子：
6.1
通讯作者：
Yao D
中科院分区：
文献类型：
--
作者：
Gong L;Zhu Y;Xu X;Li H;Guo W;Zhao Q;Yao D
Claudin 14已被证明在具有坐骨神经损伤的大鼠中在沃勒变性的早期阶段（0-4天）促进神经修复和再生，但该过程的机制仍然知之甚少。本研究报告了claudin 14对早期Wallerian变性过程中神经变性和再生的影响。Claudin 14在Wallerian变性后4天表达上调。雪旺细胞中claudin 14表达的改变导致体外细胞因子表达的变化。claudin 14的表达影响c-Jun，但不影响Akt和ERK 1/2通路。进一步研究发现claudin 14的表达增强可促进雪旺细胞的增殖和迁移。封闭蛋白14表达的沉默导致雪旺细胞凋亡和雪旺细胞增殖的减少。我们的数据揭示了claudin 14在早期Wallerian变性中的作用，这可能为Wallerian变性的分子机制提供新的见解。
Claudin 14 has been shown to promote nerve repair and regeneration in the early stages of Wallerian degeneration (0–4 days) in rats with sciatic nerve injury, but the mechanism underlying this process remains poorly understood. This study reported the effects of claudin 14 on nerve degeneration and regeneration during early Wallerian degeneration. Claudin 14 expression was up-regulated in sciatic nerve 4 days after Wallerian degeneration. The altered expression of claudin 14 in Schwann cells resulted in expression changes of cytokines in vitro. Expression of claudin 14 affected c-Jun, but not Akt and ERK1/2 pathways. Further studies revealed that enhanced expression of claudin 14 could promote Schwann cell proliferation and migration. Silencing of claudin 14 expression resulted in Schwann cell apoptosis and reduction in Schwann cell proliferation. Our data revealed the role of claudin 14 in early Wallerian degeneration, which may provide new insights into the molecular mechanisms of Wallerian degeneration.