ORALLY-ADMINISTERED MANGANESE CHLORIDE - ENHANCED DETECTION OF HEPATIC-TUMORS IN RATS
ORALLY-ADMINISTERED MANGANESE CHLORIDE - ENHANCED DETECTION OF HEPATIC-TUMORS IN RATS
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DOI：
10.1148/radiology.186.2.8421762
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发表时间：
1993-02-01
期刊：
影响因子：
19.7
通讯作者：
STARK, DD
中科院分区：
文献类型：
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作者：
KREFT, BP;BABA, Y;STARK, DD
为了评估其作为组织特异性肝胆磁共振 (MR) 造影剂的潜力，以 100-1,500 mumol/kg MnCl2 的剂量口服氯化锰，并通过离体弛豫测量和体内 MR 成像测量肝脏、胰腺、肾脏和心脏的弛豫时间。摄入200μmol/kg MnCl2后两小时，肝脏T1下降48%，而肿瘤T1仅下降9%。在自旋回波MR图像上，肝脏的信噪比增加了54%；肿瘤的对比噪声比提高了 375%。胰腺、肾脏和心脏的T1分别下降了8%、23%和13%。在主观评估中，上消化道的信号强度降低，可能是因为管腔中锰浓度高，并且肠道与其他腹部结构的轮廓得到改善。这些结果表明，口服 MnCl2 会导致肝脏显着的、可重复的、组织特异性的增强。由于肿瘤的增强程度很小，因此口服 MnCl2 可能可用于改善肝肿瘤的检测。
To evaluate its potential as a tissue-specific hepatobiliary magnetic resonance (MR) contrast agent, manganese chloride was orally administered to rats in increasing doses of 100-1,500 mumol/kg MnCl2, and the relaxation times of liver, pancreas, kidney, and heart were measured with ex vivo relaxometry and in vivo MR imaging. Two hours after ingestion of 200 mumol/kg MnCl2, liver T1 was decreased by 48%, whereas tumor T1 decreased by only 9%. On spin-echo MR images, the signal-to-noise ratio in liver increased by 54%; the contrast-to-noise ratio in tumor, by 375%. The T1 of pancreas, kidney, and heart decreased by 8%, 23%, and 13%, respectively. At subjective assessment, the signal intensity of the upper gastrointestinal tract was reduced, likely because of the high concentration of manganese in the lumen, and delineation of the intestine from other abdominal structures was improved. These results indicate that orally administered MnCl2 causes substantial, reproducible, and tissue-specific enhancement of liver. Because enhancement of tumor was minimal, orally administered MnCl2 may potentially be used to improve detection of hepatic tumors.