Multiple organ infection and the pathogenesis of SARS.
Multiple organ infection and the pathogenesis of SARS.
复制标题
多器官感染和SAR的发病机理。
DOI：
10.1084/jem.20050828
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发表时间：
2005-08-01
影响因子：
15.3
通讯作者：
Leong, Anthony S-Y
中科院分区：
文献类型：
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作者：
Gu, Jiang;Gong, Encong;Zhang, Bo;Zheng, Jie;Gao, Zifen;Zhong, Yanfeng;Zou, Wanzhong;Zhan, Jun;Wang, Shenglan;Xie, Zhigang;Zhuang, Hui;Wu, Bingquan;Zhong, Haohao;Shao, Hongquan;Fang, Weigang;Gao, Dongshia;Pei, Fei;Li, Xingwang;He, Zhongpin;Xu, Danzhen;Shi, Xeying;Anderson, Virginia M;Leong, Anthony S-Y
在全球范围内出现超过 8,000 例感染和超过 700 例死亡之后，人们对这种新型传染病——严重急性呼吸系统综合症 (SARS) 的发病机制仍然知之甚少。我们对 18 名疑似 SARS 患者的尸检进行了调查； 8例确诊为SARS。我们评估了 22 名确诊的 SARS 患者在疾病不同阶段的白细胞。还对65例确诊病例和35例误诊SARS病例的T淋巴细胞计数进行了回顾性分析。在大量循环淋巴细胞、单核细胞和淋巴组织，以及呼吸道上皮细胞、肠粘膜、肾远端小管上皮、脑神经元和不同器官的巨噬细胞中检测到SARS病毒颗粒和基因组序列。 SARS 病毒似乎能够感染多个器官中的多种细胞类型；免疫细胞和肺上皮被确定为主要损伤部位。针对SARS提出了以免疫和肺损伤为主要特征的综合发病机制理论。
After >8,000 infections and >700 deaths worldwide, the pathogenesis of the new infectious disease, severe acute respiratory syndrome (SARS), remains poorly understood. We investigated 18 autopsies of patients who had suspected SARS; 8 cases were confirmed as SARS. We evaluated white blood cells from 22 confirmed SARS patients at various stages of the disease. T lymphocyte counts in 65 confirmed and 35 misdiagnosed SARS cases also were analyzed retrospectively. SARS viral particles and genomic sequence were detected in a large number of circulating lymphocytes, monocytes, and lymphoid tissues, as well as in the epithelial cells of the respiratory tract, the mucosa of the intestine, the epithelium of the renal distal tubules, the neurons of the brain, and macrophages in different organs. SARS virus seemed to be capable of infecting multiple cell types in several organs; immune cells and pulmonary epithelium were identified as the main sites of injury. A comprehensive theory of pathogenesis is proposed for SARS with immune and lung damage as key features.