A novel RBF-based predictive tool for facial distraction surgery in growing children with syndromic craniosynostosis.
A novel RBF-based predictive tool for facial distraction surgery in growing children with syndromic craniosynostosis.
复制标题
一种基于 RBF 的新型预测工具，用于患有颅缝早闭症的成长儿童的面部牵引手术。
DOI：
10.1007/s11548-019-02063-4
复制
发表时间：
2020
影响因子：
3
通讯作者：
Angullia F
中科院分区：
文献类型：
--
作者：
Angullia F
目的：对于正在发育的颅缝早闭综合征患儿，预测其矫正手术后的面部形状变化是一个挑战。模拟面部牵引过程中复合骨和皮肤运动的预测工具将有助于手术审计和计划。为了对手术进行建模，我们使用了径向基函数（RBF），该函数在整个空间中平滑且连续，同时对应于地标处测量的牵引力。我们的目的是展示一个新的地标为基础的，RBF驱动的模拟面部牵引手术在children.MethodsAn个人的数据集包括手动放置的皮肤和骨骼的地标上操作和未操作的区域的管道。通过应用加权最小二乘RBF拟合平均地标和变化向量，为“老年人”单块，“老年人”二分区和“年轻人”二分区组产生手术翘曲。在手术扭曲之前，将从拟合RBF到颅骨测量标志与平均值的差异的“归一化”扭曲应用于每个数据集。最后逆转归一化以获得个体预测。预测进行了比较，以实际的术后outcome.ResultsThe平均变化向量为所有组显示皮肤和骨骼运动的操作特性。形状-尺寸的标准化消除了个体不对称、尺寸和比例差异，但保留了典型的术前形状特征。手术扭曲消除了平均综合征特征。逆转标准化将个体的变异重新引入预测。所有组的中面部区域都得到了很好的预测。额和眉区是不太好predicted.ConclusionsOur小说，地标为基础的，加权RBF可以预测的结果，面部分心，在年轻和年长的儿童与各种头和脸的形状。它可以在一个模型中复制复合骨和皮肤运动的手术现实。潜在的应用包括审核现有患者的结果，并预测新患者的结果，以帮助手术计划。
PurposePredicting changes in face shape from corrective surgery is challenging in growing children with syndromic craniosynostosis. A prediction tool mimicking composite bone and skin movement during facial distraction would be useful for surgical audit and planning. To model surgery, we used a radial basis function (RBF) that is smooth and continuous throughout space whilst corresponding to measured distraction at landmarks. Our aim is to showcase the pipeline for a novel landmark-based, RBF-driven simulation for facial distraction surgery in children.MethodsAn individual’s dataset comprised of manually placed skin and bone landmarks on operated and unoperated regions. Surgical warps were produced for ‘older’ monobloc, ‘older’ bipartition and ‘younger’ bipartition groups by applying a weighted least-squares RBF fitted to the average landmarks and change vectors. A ‘normalisation’ warp, from fitting an RBF to craniometric landmark differences from the average, was applied to each dataset before the surgical warp. The normalisation was finally reversed to obtain the individual prediction. Predictions were compared to actual post-operative outcomes.ResultsThe averaged change vectors for all groups showed skin and bone movements characteristic of the operations. Normalisation for shape–size removed individual asymmetry, size and proportion differences but retained typical pre-operative shape features. The surgical warps removed the average syndromic features. Reversing the normalisation reintroduced the individual’s variation into the prediction. The mid-facial regions were well predicted for all groups. Forehead and brow regions were less well predicted.ConclusionsOur novel, landmark-based, weighted RBF can predict the outcome for facial distraction in younger and older children with a variety of head and face shapes. It can replicate the surgical reality of composite bone and skin movement jointly in one model. The potential applications include audit of existing patient outcomes, and predicting outcome for new patients to aid surgical planning.