Platelet intracellular free calcium concentration in normotensive and hypertensive pregnancies in the human.
Platelet intracellular free calcium concentration in normotensive and hypertensive pregnancies in the human.
复制标题
人类正常血压和高血压妊娠时血小板细胞内游离钙浓度。
作者：
S. Barr;K. Lees;L. Butters;A. O'Donnell;P. Rubin
1. 在未怀孕妇女和妊娠晚期血压正常或有妊娠高血压或先兆子痫的患者中测量基础和刺激血小板细胞内游离钙浓度。每组15名受试者。2. 与未怀孕的受试者相比，怀孕组血小板钙水平对5-羟色胺刺激的最大反应有降低的趋势，但这仅在先兆子痫中显著。3. 在基础或腺苷5'-焦磷酸刺激的血小板细胞内游离钙浓度水平上，四组之间没有显著差异。4. 这些结果说明妊娠期高血压患者的基础血小板钙水平没有变化。基础血小板钙水平的改变可能与血小板活化无关，而血小板活化是先兆子痫的一个特征。
1. Basal and stimulated platelet intracellular free calcium concentrations were measured in non-pregnant women and in third trimester patients who were either normotensive or who had pregnancy-induced hypertension or pre-eclampsia. There were 15 subjects in each group. 2. A trend for a reduction of the maximal response of platelet calcium levels to stimulation by 5-hydroxytryptamine was seen in pregnant groups compared with nonpregnant subjects, but this was significant only in pre-eclampsia. 3. No significant differences in basal or adenosine 5'-pyrophosphate-stimulated levels of platelet intracellular free calcium concentration were observed between the four groups. 4. These results illustrate that basal platelet calcium levels are unchanged in hypertension of pregnancy. Alterations in basal platelet calcium levels may not be involved in the platelet activation that is a feature of pre-eclampsia.