Cohort Profile: The Colon Cancer Family Registry Cohort (CCFRC)
Cohort Profile: The Colon Cancer Family Registry Cohort (CCFRC)
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DOI：
10.1093/ije/dyy006
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发表时间：
2018-04-01
影响因子：
7.7
通讯作者：
Haile, Robert W.
中科院分区：
文献类型：
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作者：
Jenkins, Mark A.;Win, Aung Ko;Haile, Robert W.
结直肠癌长期以来一直是世界上最常诊断的癌症之一，2012年估计每年诊断出140万例新病例（占全球癌症诊断的9.8%），并导致69.4万例死亡（占全球所有癌症死亡的8.5%）。1 1996年，作为降低该病发病率和死亡率的承诺，美国国立卫生研究院国家癌症研究所（NCI）邀请研究人员申请资金，以建立“结直肠癌患者合作家庭登记”（RFA：CA-96-011）。NIH声明的主要目标是：收集患有和没有结直肠癌以及有和没有该疾病家族史的参与者的谱系信息、流行病学数据和相关生物样本，作为结直肠癌病因学跨学科研究的资源;并确定可以从预防策略中受益的结直肠癌高风险人群。
Colorectal cancer has long been one of the most frequently diagnosed cancers in the world, with an estimated 1.4 million new cases diagnosed each year (9.8% of worldwide cancer diagnoses) and the cause of 694 000 deaths (8.5% of all worldwide cancer deaths) in 2012. 1 In 1996, as a commitment to reduce morbidity and mortality from this disease, the National Cancer Institute (NCI) of the US National Institutes of Health invited investigators to apply for funding to establish a ‘Cooperative Family Registry for Colorectal Cancer Studies’(RFA: CA-96-011). The main NIH stated aims were: to collect pedigree information, epidemiological data and related biological specimens from participants with and without colorectal cancer and with and without a family history of the disease, as a resource for interdisciplinary studies on the aetiology of colorectal cancer; and to identify a population at high risk of colorectal cancer that could benefit from preventive strategies.