AMP-activated Protein Kinase (AMPK): Does This Master Regulator of Cellular Energy State Distinguish Insulin Sensitive from Insulin Resistant Obesity?
AMP-activated Protein Kinase (AMPK): Does This Master Regulator of Cellular Energy State Distinguish Insulin Sensitive from Insulin Resistant Obesity?
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DOI：
10.1007/s13679-014-0095-x
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发表时间：
2014-06-01
影响因子：
8.8
通讯作者：
Ruderman, Neil B
中科院分区：
文献类型：
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作者：
Xu, X Julia;Valentine, Rudy J;Ruderman, Neil B
虽然肥胖和胰岛素抵抗之间存在相关性，但大约25%的肥胖个体是胰岛素敏感的。AMP激活蛋白激酶（AMPK）是一种细胞能量传感器，在其许多作用中，整合多种生理信号以恢复能量平衡。此外，在许多情况下，它也会增加胰岛素敏感性。在这种情况下，与胰岛素敏感的同样肥胖的患者相比，接受减肥手术的胰岛素抵抗的非常肥胖的个体中AMPK活性降低。在这篇综述中，我们将探讨这些个体的区别，并评估AMPK减少与胰岛素抵抗和代谢综合征相关疾病在其他情况下的证据。
Although a correlation exists between obesity and insulin resistance, roughly 25 % of obese individuals are insulin sensitive. AMP-activated protein kinase (AMPK) is a cellular energy sensor that among its many actions, integrates diverse physiological signals to restore energy balance. In addition, in many situations it also increases insulin sensitivity. In this context, AMPK activity is decreased in very obese individuals undergoing bariatric surgery who are insulin resistant compared to equally obese patients who are insulin sensitive. In this review, we will both explore what distinguishes these individuals, and evaluate the evidence that diminished AMPK is associated with insulin resistance and metabolic syndrome-associated disorders in other circumstances.