A randomized-controlled trial of low-dose doxycycline for periodontitis in smokers.
A randomized-controlled trial of low-dose doxycycline for periodontitis in smokers.
复制标题
低剂量多西环素治疗吸烟者牙周炎的随机对照试验。
DOI：
10.1111/j.1600-051x.2007.01058.x
复制
发表时间：
2007
影响因子：
6.7
通讯作者：
Jarvis,Martin
中科院分区：
文献类型：
--
作者：
Needleman,Ian;Suvan,Jean;Gilthorpe,MarkS;Tucker,Richard;StGeorge,Geoff;Giannobile,William;Tonetti,Maurizio;Jarvis,Martin
AbstractBackground/Aim:Tobacco use reduces the effect of non‐surgical periodontal therapy. Host‐modulation with low‐dose doxycycline (LDD) might favour repair and promote an improved treatment response. The aim of this study was to investigate the effect of LDD in smokers on non‐surgical periodontal therapy.Material and Methods:This was a parallel arm, randomized, identical placebo‐controlled trial with masking of examiner, care‐giver, participant and statistician and 6 months of follow‐up. Patients received non‐surgical therapy and 3 months of test or control drug. Statistical analysis used both conventional methods and multilevel modelling.Results:Eighteen control and 16 test patients completed the study. The velocity of change was statistically greater for the test group for clinical attachment level −0.19 mm/month (95% CI=−0.34, 0.04;p=0.012) and probing depth 0.30 mm/month (95% CI=−0.42, −0.17;p<0.001). However, no differences were observed for absolute change in clinical or biochemical markers at 6 months.Conclusions:This study does not provide evidence of a benefit of using LDD as an adjunct to non‐surgical periodontal therapy in smokers.
