Absolute coding of stimulus novelty in the human substantia nigra/VTA
Absolute coding of stimulus novelty in the human substantia nigra/VTA
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DOI：
10.1016/j.neuron.2006.06.021
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发表时间：
2006-08-03
期刊：
影响因子：
16.2
通讯作者：
Duzel, Emrah
中科院分区：
文献类型：
--
作者：
Bunzeck, Nico;Duzel, Emrah
新奇探索可以通过黑质/腹侧被盖区（SN/VTA）产生的多巴胺能神经调节来增强动物海马的可塑性。这种增强可以比探索阶段持续几分钟。目前，人们对多巴胺能神经元的新奇性加工及其与人类海马功能的关系知之甚少。在两项功能性磁共振成像（fMRI）研究中，人类的SN/VTA激活确实是由刺激新奇性驱动的，而不是其他形式的刺激显着性，如稀有性，负面情绪效价，或熟悉刺激的靶向性，而海马反应的选择性较低。SN/VTA的新奇反应是根据绝对的，而不是相对的新奇在给定的情况下，缩放，不像适应性SN/VTA反应最近报告的奖励结果在动物研究。最后，新奇增强了在相同背景下对熟悉项目的学习和嗅周/海马旁处理。因此，人类SN/VTA可以编码绝对刺激新奇性，并可能有助于增强新奇性背景下的学习。
Novelty exploration can enhance hippocampal plasticity in animals through dopaminergic neuromodulation arising in the substantia nigra/ventral tegmental area (SN/VTA). This enhancement can outlast the exploration phase by several minutes. Currently, little is known about dopaminergic novelty processing and its relationship to hippocampal function in humans. In two functional magnetic resonance imaging (fMRI) studies, SN/VTA activations in humans were indeed driven by stimulus novelty rather than other forms of stimulus salience such as rareness, negative emotional valence, or targetness of familiar stimuli, whereas hippocampal responses were less selective. SN/VTA novelty responses were scaled according to absolute rather than relative novelty in a given context, unlike adaptive SN/VTA responses recently reported for reward outcome in animal studies. Finally, novelty enhanced learning and perirhinal/parahippocampal processing of familiar items presented in the same context. Thus, the human SN/VTA can code absolute stimulus novelty and might contribute to enhancing learning in the context of novelty.