Endoscopic, rapid near-infrared optical tomography.
Endoscopic, rapid near-infrared optical tomography.
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DOI：
10.1364/ol.31.002876
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发表时间：
2006-10
期刊：
影响因子：
3.6
通讯作者：
D. Piao;H. Xie;Weili Zhang;J. Krasinski;Guolong Zhang;H. Dehghani;B. Pogue
中科院分区：
文献类型：
--
作者：
D. Piao;H. Xie;Weili Zhang;J. Krasinski;Guolong Zhang;H. Dehghani;B. Pogue
这被认为是近红外（NIR）光学断层扫描在内窥镜规模和快速采样速度，允许翻译到体内使用的第一个演示。基于宽带光源和线性到圆形光纤束的扩频编码技术用于提供用于断层扫描的许多源-检测器光纤的内窥镜探测以及用于快速成像的所有源-检测器对的并行采样。内窥镜近红外断层扫描在8 Hz的帧速率，实现了在幻影和组织标本与12毫米探头外壳8个源和8个探测器。这种新的方法提供了关键的可行性研究，允许这种基于血液的对比成像技术尝试通过内窥镜检查检测内部器官中的癌症。
This is believed to be the first demonstration of near-infrared (NIR) optical tomography employed at the endoscope scale and at a rapid sampling speed that allows translation to in vivo use. A spread-spectral-encoding technique based on a broadband light source and linear-to-circular fiber bundling was used to provide endoscopic probing of many source-detector fibers for tomography as well as parallel sampling of all source-detector pairs for rapid imaging. Endoscopic NIR tomography at an 8 Hz frame rate was achieved in phantoms and tissue specimens with a 12 mm probe housing eight sources and eight detectors. This novel approach provides the key feasibility studies to allow this blood-based contrast imaging technology to be attempted in detection of cancer in internal organs via endoscopic interrogation.