Cerebral ischemia mediates the effect of serum uric acid on cognitive function.
Cerebral ischemia mediates the effect of serum uric acid on cognitive function.
复制标题
DOI：
10.1161/strokeaha.108.521591
复制
发表时间：
2008-12
期刊：
影响因子：
8.3
通讯作者：
Schretlen DJ
中科院分区：
文献类型：
--
作者：
Vannorsdall TD;Jinnah HA;Gordon B;Kraut M;Schretlen DJ
血清尿酸（UA）正常浓度高与轻度认知功能障碍和白质高信号体积指示的脑缺血增加有关。我们假设白质高信号的个体差异介导了UA和轻度认知功能障碍之间的关联。一百八十名年龄在 20 岁至 96 岁之间的社区居民完成了神经心理学测试、实验室血液研究和脑部 MRI 扫描。血清UA与较高的白质高信号和较差的工作记忆、处理速度、流畅性和语言记忆相关（P<0.05）。在控制了年龄、性别、种族、教育程度、高血压、糖尿病、酗酒、吸烟和体重后，关联仍然存在。添加白质高信号这一术语削弱了这些关联，使得 UA 不再预测认知能力。脑缺血的严重程度可能介导UA与认知功能障碍之间的关联。即使UA的轻微升高似乎也会导致大脑结构和功能的变化。
High normal concentrations of serum uric acid (UA) are associated with mild cognitive dysfunction and increased cerebral ischemia as indexed by white matter hyperintensity volumes. We hypothesized that individual differences in white matter hyperintensities mediate the association between UA and mild cognitive dysfunction. One hundred eighty community-dwelling adults aged 20 to 96 years completed neuropsychological testing, laboratory blood studies, and a brain MRI scan. Serum UA was associated (P<0.05) with greater white matter hyperintensities and poorer working memory, processing speed, fluency, and verbal memory. Associations remained after controlling for age, sex, race, education, hypertension, diabetes, alcohol abuse, smoking, and body mass. Adding a term for white matter hyperintensity attenuated these associations such that UA no longer predicted cognitive performance. Severity of cerebral ischemia might mediate the association between UA and cognitive dysfunction. Even mild elevations in UA appear to contribute to structural and functional brain changes.