Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis
Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis
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DOI：
10.1053/j.gastro.2018.12.042
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发表时间：
2019-05-01
期刊：
影响因子：
29.4
通讯作者：
Banerjee, Sulagna
中科院分区：
文献类型：
--
作者：
Crawford, Howard C.;di Magliano, Marina Pasca;Banerjee, Sulagna
胰腺导管腺癌是最致命的癌症之一，其发病率呈上升趋势。克服这种疾病预后不良的主要挑战包括晚期发现和疾病的侵袭性生物学。瘤内异质性;一个强大的，反应性的，促结缔组织增生的基质的存在;和不同的肿瘤成分之间的串扰需要完整的胰腺肿瘤生物学的理解，以更好地理解这种疾病带来的治疗挑战。在这篇综述中，我们讨论了肿瘤发生过程中所涉及的过程，包括转化细胞的固有可塑性，肿瘤间质串扰的发展，以及肿瘤发生过程中肿瘤干细胞群的富集。
Pancreatic ductal adenocarcinoma is one of the deadliest cancers, and its incidence on the rise. The major challenges in overcoming the poor prognosis with this disease include late detection and the aggressive biology of the disease. Intratumoral heterogeneity; presence of a robust, reactive, and desmoplastic stroma; and the crosstalk between the different tumor components require complete understanding of the pancreatic tumor biology to better understand the therapeutic challenges posed by this disease. In this review, we discuss the processes involved during tumorigenesis encompassing the inherent plasticity of the transformed cells, development of tumor stroma crosstalk, and enrichment of cancer stem cell population during tumorigenesis.