Age-associated changes in regenerative capabilities of mesenchymal stem cell: impact on chronic wounds repair
Age-associated changes in regenerative capabilities of mesenchymal stem cell: impact on chronic wounds repair
复制标题
间充质干细胞再生能力与年龄相关的变化：对慢性伤口修复的影响
DOI：
10.1111/iwj.12491
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发表时间：
2016
影响因子：
3.1
通讯作者：
Fu Xiaobing
中科院分区：
文献类型：
--
作者：
Yao Bin;Huang Sha;Gao Dongyun;Xie Jiangfan;Liu Nanbo;Fu Xiaobing
间充质干细胞（MSC）是慢性伤口自体细胞治疗的理想来源。MSC的功能特性可能通过发挥其多再生潜力而有利于伤口愈合。然而，由慢性退行性疾病或供体年龄引起的细胞老化可能会对MSC的再生能力造成不可避免的影响。各种研究已经显示了MSC老化和年龄相关功能障碍之间的关系，但很少将这些年龄相关的MSC影响与其修复慢性伤口的能力联系起来，这在老年人群中很常见。在这里，我们讨论了MSC的年龄相关变化，并描述了对慢性伤口MSC为基础的治疗的潜在影响。此外，对目前文献的批判性评价对于理解MSC老化的潜在机制和考虑其可能用于慢性伤口修复的相应关注是必要的。
Mesenchymal stem cells (MSCs) represent an ideal source of autologous cell‐based therapy for chronic wounds. Functional characteristics of MSCs may benefit wound healing by exerting their multi‐regenerative potential. However, cell ageing resulting from chronic degenerative diseases or donor age could cause inevitable effects on the regenerative abilities of MSCs. A variety of studies have shown the relationship between MSC ageing and age‐related dysfunction, but few associate these age‐related impacts on MSCs with their ability of repairing chronic wounds, which are common in the elderly population. Here, we discuss the age‐associated changes of MSCs and describe the potential impacts on MSC‐based therapy for chronic wounds. Furthermore, critical evaluation of the current literatures is necessary for understanding the underlying mechanisms of MSC ageing and raising the corresponding concerns on considering their possible use for chronic wound repair.