Circadian variations of vasoconstriction and blood pressure in physiology and diabetes.

Circadian variations of vasoconstriction and blood pressure in physiology and diabetes.
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DOI:
10.1016/j.coph.2021.02.001
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发表时间:
2021-04
影响因子:
4
通讯作者:
Gong MC
Gong MC
中科院分区:
医学3区
文献类型:
--
作者:
Hou T;Guo Z;Gong MC

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The intrinsic vascular smooth muscle contraction and vasoconstriction show time-of-day variations, contributing to the blood pressure circadian rhythm, which is essential for cardiovascular health. This brief review provides an overview of our current understanding of the mechanisms underlying the time-of-day variations of vascular smooth muscle contraction. We discuss the potential contribution of the time-of-day variations of vasoconstriction to the physiological blood pressure circadian rhythm. Finally, we survey the data obtained in the type 2 diabetic db/db mouse model that demonstrate the alterations of the time-of-day variations of vasoconstriction and the non-dipping blood pressure in diabetes.
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