IGG SUBCLASS RESPONSES TO PSEUDOMONAS-AERUGINOSA A-TYPE AND B-TYPE FLAGELLINS IN PATIENTS WITH CYSTIC-FIBROSIS - A PROSPECTIVE-STUDY
IGG SUBCLASS RESPONSES TO PSEUDOMONAS-AERUGINOSA A-TYPE AND B-TYPE FLAGELLINS IN PATIENTS WITH CYSTIC-FIBROSIS - A PROSPECTIVE-STUDY
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DOI：
10.1099/00222615-43-4-270
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发表时间：
1995-10-01
影响因子：
3
通讯作者：
MONTIE, TC
中科院分区：
文献类型：
--
作者：
LAGACE, J;PELOQUIN, L;MONTIE, TC
对20例肺部铜绿假单胞菌定植的囊性纤维化患者的血清进行了3-5年的前瞻性研究，以了解抗铜绿假单胞菌a、b型鞭毛蛋白的Ig G亚类抗体水平与肺功能(FEV和放射学评分)之间的关系。根据患者的肺状况分为两组：第一组为肺状况较差的11例，第二组为肺状况较好的9例。在大多数患者中发现了高浓度的鞭毛抗体，尤其是b型抗体。仅在少数患者中观察到IgG4反应。两组患者的比较显示，肺状况较差的患者(第1组)在研究的三个时期中有两个时期的IgG3浓度显著高于(p<；0.05)，在研究的最后一个时期的IgG2浓度显著高于对照组。此外，第1组患者的IgG3和IgG1对b型鞭毛蛋白的反应性和IgG3对a型鞭毛蛋白的反应性在研究的第一个时期和最后一个时期也显著增加(p<；0.05)。这些患者的IgG3和IgG1抗体浓度也显示出显著的(p<；0.05)时间依赖性增加。这些数据表明，肺状况较差的囊性纤维化患者对鞭毛蛋白的IgG3水平高于其他囊性纤维化患者。高浓度的强效IgG3和较轻程度的IgG1抗体可能会增加肺部炎症并导致肺恶化加剧。
Sera from 20 cystic fibrosis patients, whose lungs were colonised by Pseudomonas aeruginosa, were examined in a 3-5-year prospective study for any relationship between IgG subclass antibody levels to P. aeruginosa a- and b-type flagellins and pulmonary function (FEV, and radiological score). Patients were divided into two groups according to their pulmonary status: group 1 comprised 11 patients with poor pulmonary status; group 2 comprised nine patients with relatively good pulmonary status. High concentrations of IgG1, IgG2 and IgG3 antibodies to flagellins, particularly to the b-type, were found in most patients. IgG4 reactivity was observed in only a few patients. Comparison of the two groups of patients showed that those with poor pulmonary status (group 1) had a significantly higher concentration (p < 0.05) of IgG3 for two of the three periods studied and of IgG2 for the last period studied. Moreover, IgG3 and IgG1 reactivities to b-type flagellin and IgG3 to a-type flagellin were also increased significantly (p < 0.05) in group 1 patients between the first and the last period studied. These patients also showed a significant (p < 0.05) time-dependent increase in IgG3 and IgG1 antibody concentrations. These data demonstrate that cystic fibrosis patients with poorer pulmonary status have higher IgG3 levels to flagellin than other cystic fibrosis patients. High concentrations of strong opsonic IgG3 and, to a lesser degree, of IgG1 antibodies may increase pulmonary inflammation and induce heightened pulmonary deterioration.