Effect of Sucralfate on the Peptic Degradation of Gastric Mucin a
Effect of Sucralfate on the Peptic Degradation of Gastric Mucin a
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硫糖铝对胃粘蛋白a消化性降解的影响
DOI：
10.1111/j.1749-6632.1986.tb21577.x
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发表时间：
1986
影响因子：
5.2
通讯作者：
B. Slomiany
中科院分区：
文献类型：
--
作者：
W. Laszewicz;Y. H. Liau;A. Slomiany;B. Slomiany
胃肠道的上皮表面受到大量粘性粘液的保护，免受管腔内容物的酸和胃蛋白酶的破坏作用。负责粘液粘弹性特性、其完整性和强度的成分是一种称为粘蛋白的高分子量 (-2.0 x lo6) 糖蛋白。“胃内胃蛋白酶对粘液凝胶的持续侵蚀会导致这种糖蛋白的聚合结构被破坏，从而导致粘液保护能力的丧失。”在正常生理条件下，可再生的粘液层可以有效地抵消粘液糖蛋白侵蚀的程度。这种平衡的紊乱通常与胃病有关。用于控制过度消化道攻击的药物之一是硫糖铝。本研究的目的是评估硫糖铝对胃粘液糖蛋白消化性降解的影响。
The epithelial surfaces of the gastrointestinal tract are protected from the damaging effects of acid and pepsin of luminal Content by copious quantities of a viscous mucus. The component responsible for the viscoelastic properties of mucus, its integrity, and strength is a high-molecular-weight (-2.0 x lo6) glycoprotein called mucin.’.’ Continuous erosion of the mucus gel by intragastric pepsin leads to destruction of the polymeric structure of this glycoprotein and consequently to the loss of the protective capacity of mucus.’ Under normal physiological conditions, the extent of mucus glycoprotein erosion is efficiently countered by renewable mucus coat. The disturbances in this balance are often associated with gastric disease. Among the agents used to control the excessive peptic aggression is sucralfate. The purpose of this study was to evaluate the effect of sucralfate on the peptic degradation of gastric mucus glycoprotein.
乙醇对胃粘液糖蛋白消化性降解的影响。
影响因子：
3.2
作者：
Laszewicz,W;Slomiany,A;Murty,VL;Liau,YH;Slomiany,BL
通讯作者：
Slomiany,BL
与狗胃粘液糖蛋白相关的脂质。
DOI：
--
发表时间：
1983
期刊：
Journal of applied biochemistry
影响因子：
--
作者：
Witas,H;Slomiany,BL;Zdebska,E;Kojima,K;Liau,YH;Slomiany,A
通讯作者：
Slomiany,A