Preoperative natural killer cell activity as a prognostic factor for distant metastasis following surgery for colon cancer
Preoperative natural killer cell activity as a prognostic factor for distant metastasis following surgery for colon cancer
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DOI：
10.1159/000072714
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发表时间：
2003-01-01
影响因子：
2.7
通讯作者：
Miyazaki, M
中科院分区：
文献类型：
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作者：
Kondo, E;Koda, K;Miyazaki, M
背景/目的：确定结肠癌患者术前自然杀伤(NK)细胞活性是否具有预后意义。方法：研究对象为140例结肠癌患者。128名患者在手术前2周内和其余12名未接受手术或仅接受姑息手术的患者在确诊时测定了NK细胞活性。观察病情进展和术后预后与NK细胞活性的关系。结果：NK细胞活性下降与肿瘤分期无关。在手术治疗的I-III期疾病中，术前NK细胞活性为20%或更低的患者存活率较低。低活动性也与异时性远处转移有关，但与局部复发无关。特别是，在NK细胞活性减弱的III期患者中，超过一半发生了转移。多因素分析表明，NK细胞活性降低是预测结肠癌根治术后远处转移的重要指标。结论：术前NK细胞活性对结肠癌根治性手术患者的预后有重要价值，尤其是对III期患者的异时性远处转移的预测价值更大。版权所有(C)2003 S.Karger AG，巴塞尔。
Background/Aims: To determine whether preoperative natural killer (NK) cell activity has any prognostic significance in colon cancer patients. Methods: The study population consisted of 140 patients with colon cancer. NK cell activity was determined within 2 weeks before surgery in 128 patients and at the time of diagnosis in the remaining 12 patients who either did not undergo surgery or who underwent palliative surgery only. Disease progression and postoperative prognosis were examined in relation to NK cell activity. Results: Decreases in NK cell activity did not necessarily correspond to tumor stage. In curatively operated stage I-III diseases, preoperative NK cell activity of 20% or less correlated with poor survival. Lower activity was also associated with metachronous distant metastases but not with local recurrences. In particular, more than half the stage III patients with attenuated NK cell activity developed metastases. Multivariate analysis indicated that attenuated NK cell activity was a significant parameter for predicting distant metastasis following curative surgery for colon cancer. Conclusion: Preoperative NK cell activity has a significant prognostic value in curatively operated colon cancer, particularly for the development of metachronous distant metastasis in stage III patients. Copyright (C) 2003 S. Karger AG, Basel.